MolNFT v1 · #44157 · protein

Intermolecular interactions between neurotensin and the third extracellular loop of human neurotensin 1 receptor

2LYW · Neurotensin receptor type 1: “Intermolecular interactions between neurotensin and the third extracellular loop of human neurotensin 1…”. Solution nmr. MolNFT v1 #44157 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 2LYW
Type: protein
Length: 37 residues
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Neurotensin receptor type 1; Neurotensin
UniProt: P30989, P30990

Structure

solution nmr · 2 distinct chains · 0% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Neurotensin receptor type 1	protein	24	0% helix, 0% strand	P30989
B	Neurotensin	protein	13	0% helix, 0% strand	P30990

Interfaces

1 interface between chains.

A–B · 748 Å² buried · 13 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 1 modified (cyclization).

Compared structures

2LYW · Intermolecular interactions between neurotensin and the third extracellular loop of human… · the same entry in another collection · chain A against A, TM-score 1.00
P30990 · AlphaFold monomer V2.0 prediction for NEUROTENSIN/NEUROMEDIN N (P30990) · a predicted model of the same protein · chain B against A, TM-score 0.23
P30989 · AlphaFold monomer V2.0 prediction for neurotensin receptor type 1 (P30989) · a predicted model of the same protein · chain A against A, TM-score 0.17

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P30989
Every structure of UniProt P30990
Elsewhere: RCSB PDB 2LYW · PDBe 2LYW · UniProt P30989 · UniProt P30990

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