UniProt P08754
Guanine nucleotide-binding protein G(i) subunit alpha-3 (P08754)
Guanine nucleotide-binding protein G(i) subunit alpha-3 (UniProt P08754): 21 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 10 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P08754
- Protein
- Guanine nucleotide-binding protein G(i) subunit alpha-3
- Experimental structures
- 21
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 10 · 3 records with a druggable one
Structures
22 records of P08754 in the MolNFT archive: 21 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2IHB | Crystal structure of the heterodimeric complex of human RGS10 and activated Gi alpha 3 | x-ray diffraction | A | — | — |
| 2IHB | Crystal structure of the heterodimeric complex of human RGS10 and activated gi alpha 3 | x-ray diffraction | A | — | — |
| 2ODE | Crystal structure of the heterodimeric complex of human RGS8 and activated Gi alpha 3 | x-ray diffraction | A, C | — | — |
| 2ODE | Crystal structure of the heterodimeric complex of human RGS8 and activated gi alpha 3 | x-ray diffraction | A, C | — | — |
| 2V4Z | The crystal structure of the human G-protein subunit alpha (GNAI3) in complex with an engineered… | x-ray diffraction | A | — | — |
| 2V4Z | The crystal structure of the human G-protein subunit alpha (GNAI3) in complex with an engineered… | x-ray diffraction | A | — | — |
| 4G5O | Structure of LGN GL4/Galphai3(Q147L) complex | x-ray diffraction | A, B, C, D | — | — |
| 4G5O | Structure of lgn GL4/GALPHAI3(Q147L) complex | x-ray diffraction | A, B, C, D | — | — |
| 4G5R | Structure of LGN GL4/Galphai3 complex | x-ray diffraction | A, B, C, D | — | — |
| 4G5R | Structure of lgn GL4/GALPHAI3 complex | x-ray diffraction | A, B, C, D | — | — |
| 4G5S | Structure of LGN GL3/Galphai3 complex | x-ray diffraction | A, B, C, D | — | — |
| 4G5S | Structure of lgn GL3/GALPHAI3 complex | x-ray diffraction | A, B, C, D | — | — |
| 7E9H | Cryo-EM structure of gi-bound metabotropic glutamate receptor MGLU4 | electron microscopy | A | — | — |
| 7KH0 | Cryo-EM structure of the human arginine vasopressin avp-vasopressin receptor V2R-gs signaling… | electron microscopy | A | — | — |
| 7RA3 | Cryo-EM of human gastric inhibitory polypeptide receptor gipr bound to gip | electron microscopy | A | — | — |
| 7RGP | Cryo-EM of human glucagon-like peptide 1 receptor glp-1R bound to tirzepatide | electron microscopy | A | — | — |
| 7T10 | Cryoem structure of somatostatin receptor 2 in complex with somatostatin-14 and GI3 | electron microscopy | A | — | — |
| 7T11 | Cryoem structure of somatostatin receptor 2 in complex with octreotide and GI3. | electron microscopy | A | — | — |
| 8JD6 | Cryo-EM structure of Gi1-bound metabotropic glutamate receptor mGlu4 | electron microscopy | A | — | 5 (best 0.80) |
| 8OY1 | Structure of the human Guanine Nucleotide-Binding Protein G(K) Subunit Alpha | x-ray diffraction | A | GDP | 2 (best 0.77) |
| 8WGB | mGlu2-4 heterodimer bound with Gi | electron microscopy | C | — | 3 (best 0.83) |
| P08754 | AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I) subunit alpha-3… | predicted | A | — | — |
Ligands
- GDP · Guanosine-5'-diphosphate · in 1 record
Experiment against prediction
- 2V4Z chain A against the predicted model P08754: TM-score 0.99, RMSD 0.61 Å
- 2V4Z chain A against the predicted model P08754: TM-score 0.99, RMSD 0.61 Å
- 2IHB chain A against the predicted model P08754: TM-score 0.99, RMSD 0.80 Å
- 2IHB chain A against the predicted model P08754: TM-score 0.99, RMSD 0.80 Å
- 2ODE chain A against the predicted model P08754: TM-score 0.99, RMSD 0.85 Å
- 2ODE chain A against the predicted model P08754: TM-score 0.99, RMSD 0.85 Å
- 2ODE chain C against the predicted model P08754: TM-score 0.98, RMSD 0.91 Å
- 2ODE chain C against the predicted model P08754: TM-score 0.98, RMSD 0.91 Å
- 8OY1 chain A against the predicted model P08754: TM-score 0.96, RMSD 1.53 Å
- 4G5S chain D against the predicted model P08754: TM-score 0.96, RMSD 1.75 Å
Elsewhere
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