MolNFT v1 · #187407 · protein
FH210 bound mu opioid receptor-gi protein complex
7SCG · Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit…: “FH210 bound mu opioid receptor-gi protein complex”. Electron microscopy, 1 ligand (8RI), 13 pockets (best druggability 0.82). MolNFT v1 #187407 on GenesisL1: 3D structure…
- PDB
- 7SCG
- Type
- protein
- Length
- 1,121 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1; Guanine…
- UniProt
- P62873, P59768, P42866, P63096
- Ligands
- 8RI
- Pockets
- 13 · best druggability 0.82
Structure
electron microscopy · 5 distinct chains · 33% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | protein | 336 | 5% helix, 49% strand | P62873 |
| C | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | protein | 53 | 51% helix, 0% strand | P59768 |
| D | Mu-type opioid receptor | protein | 283 | 80% helix, 4% strand | P42866 |
| A | Guanine nucleotide-binding protein G(I) subunit alpha-1 | protein | 217 | 44% helix, 17% strand | P63096 |
| E | SCFV16 | protein | 232 | 3% helix, 46% strand | — |
Ligands and binding sites
- 8RI · (2E)-N-[(2S)-2-(dimethylamino)-3-(4-hydroxyphenyl) propyl]-3-(naphthalen-1-yl)prop-2-enamide · ligand · chains D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
13 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 923 | 0.82 | 0.84 | 60 | empty |
| 2 | 719 | 0.76 | 0.81 | 47 | 8RI |
| 3 | 615 | 0.65 | 0.75 | 64 | empty |
| 4 | 295 | 0.57 | 0.77 | 37 | empty |
| 5 | 219 | 0.57 | 0.79 | 34 | empty |
Interfaces
5 interfaces between chains.
- B–C · 2074 Ų buried · 7 hydrogen bonds · protein-protein
- D–A · 1207 Ų buried · 4 hydrogen bonds · protein-protein
- B–A · 1134 Ų buried · 11 hydrogen bonds · protein-protein
- A–E · 528 Ų buried · 4 hydrogen bonds · protein-protein
- B–E · 349 Ų buried · 2 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 3 disulfide (disulfide).
Compared structures
- 7SCG · FH210 bound Mu Opioid Receptor-Gi Protein Complex · the same entry in another collection · chain E against E, TM-score 1.00
- P62873 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain B against A, TM-score 0.99
- P42866 · AlphaFold monomer V2.0 prediction for mu-type opioid receptor (P42866) · a predicted model of the same protein · chain D against A, TM-score 0.95
- P59768 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(O)… · a predicted model of the same protein · chain C against A, TM-score 0.88
- P63096 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I) subunit… · a predicted model of the same protein · chain A against A, TM-score 0.81
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P62873
- Every structure of UniProt P59768
- Every structure of UniProt P42866
- Every structure of UniProt P63096
- Elsewhere: RCSB PDB 7SCG · PDBe 7SCG · UniProt P62873 · UniProt P59768 · UniProt P42866 · UniProt P63096
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