UniProt P42866
Mu-type opioid receptor (P42866)
Mu-type opioid receptor (UniProt P42866): 16 experimental structures and 1 predicted model on GenesisL1, 10 ligands bound, 32 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P42866
- Protein
- Mu-type opioid receptor
- Experimental structures
- 16
- Predicted models
- 1
- Ligands
- 10
- Pockets
- 32 · 8 records with a druggable one
Structures
17 records of P42866 in the MolNFT archive: 16 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4DKL | Crystal structure of the mu-opioid receptor bound to a morphinan antagonist | x-ray diffraction | A | — | — |
| 4DKL | Crystal structure of the mu-opioid receptor bound to a morphinan antagonist | x-ray diffraction | A | — | — |
| 5C1M | Crystal structure of active mu-opioid receptor bound to the agonist BU72 | x-ray diffraction | A | CLR, PO4, VF1 | 5 (best 0.84) |
| 5C1M | Crystal structure of active mu-opioid receptor bound to the agonist BU72 | x-ray diffraction | A | — | — |
| 6DDE | Mu opioid receptor-gi protein complex | electron microscopy | R | ETA | — |
| 6DDF | Mu Opioid Receptor-Gi Protein Complex | electron microscopy | R | — | 3 (best 0.68) |
| 6DDF | Mu opioid receptor-gi protein complex | electron microscopy | R | ETA | — |
| 7SBF | PZM21 bound mu opioid receptor-gi protein complex | electron microscopy | R | 8QY | — |
| 7SCG | FH210 bound Mu Opioid Receptor-Gi Protein Complex | electron microscopy | D | 8RI | 5 (best 0.76) |
| 7SCG | FH210 bound mu opioid receptor-gi protein complex | electron microscopy | D | 8RI | — |
| 7U2K | C6-guano bound Mu Opioid Receptor-Gi Protein Complex | electron microscopy | D | KZR | 4 (best 0.75) |
| 7U2L | C5GUANO-uor-gi-SCFV16 | electron microscopy | D | L0X | — |
| 7UL4 | CryoEM Structure of Inactive MOR Bound to Alvimopan and Mb6 | electron microscopy | A | NG0 | 3 (best 0.71) |
| 7UL4 | Cryoem structure of inactive mor bound to alvimopan and MB6 | electron microscopy | A | NG0 | — |
| 8QOT | Structure of the mu opioid receptor bound to the antagonist nanobody NbE | electron microscopy | A | — | 5 (best 0.72) |
| 9BQJ | RO76 bound muOR-Gi1-scFv16 complex structure | electron microscopy | D | A1AQ2 | 5 (best 0.78) |
| P42866 | AlphaFold monomer V2.0 prediction for mu-type opioid receptor (P42866) | predicted | A | — | 2 (best 0.77) |
Ligands
- 8RI · (2E)-N-[(2S)-2-(dimethylamino)-3-(4-hydroxyphenyl) propyl]-3-(naphthalen-1-yl)prop-2-enamide · in 2 records
- ETA · Ethanolamine · in 2 records
- NG0 · N-[(2S)-2-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]methyl}-3-phenylpropanoyl]glycine · in 2 records
- 8QY · N-[(2S)-2-(dimethylamino)-3-(4-hydroxyphenyl)propyl]-N'-[(2S)-1-(thiophen-3-yl)propan-2-yl]urea · in 1 record
- A1AQ2 · N-{[3-(hydroxymethyl)phenyl]methyl}-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide · in 1 record
- CLR · Cholesterol · in 1 record
- KZR · N-(6-carbamimidamidohexyl)-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide · in 1 record
- L0X · N-(5-carbamimidamidopentyl)-N-[1-(2-phenylethyl) piperidin-4-yl]propanamide · in 1 record
- PO4 · Phosphate ion · in 1 record
- VF1 · (2R,3S,3aR,5aR,6R,11bR,11cS)-3a-methoxy-3,14-dimethyl-2-phenyl-2,3,3a,6,7,11c-hexahydro-1H-6,11b-(epiminoethano)-3,5a-methanonaphtho[2,1-g]indol-10-ol · in 1 record
Experiment against prediction
- 7U2L chain D against the predicted model P42866: TM-score 0.96, RMSD 1.55 Å
- 7SBF chain R against the predicted model P42866: TM-score 0.96, RMSD 1.51 Å
- 7SCG chain D against the predicted model P42866: TM-score 0.95, RMSD 1.62 Å
- 7SCG chain D against the predicted model P42866: TM-score 0.95, RMSD 1.62 Å
- 9BQJ chain D against the predicted model P42866: TM-score 0.95, RMSD 1.63 Å
- 6DDF chain R against the predicted model P42866: TM-score 0.95, RMSD 1.64 Å
- 6DDF chain R against the predicted model P42866: TM-score 0.95, RMSD 1.64 Å
- 7U2K chain D against the predicted model P42866: TM-score 0.95, RMSD 1.69 Å
- 6DDE chain R against the predicted model P42866: TM-score 0.95, RMSD 1.67 Å
- 5C1M chain A against the predicted model P42866: TM-score 0.93, RMSD 1.56 Å
Elsewhere
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