AlphaFold monomer V2.0 prediction for mu-type opioid receptor (P42866)

Structure

1 distinct chain · 70% helix, 3% strand (DSSP).

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

• 5C1M · Crystal structure of active mu-opioid receptor bound to the agonist BU72 · an experimental structure of the same protein · chain A against A, TM-score 0.70
• 7U2L · C5GUANO-uor-gi-SCFV16 · an experimental structure of the same protein · chain A against D, TM-score 0.69
• 7SCG · FH210 bound mu opioid receptor-gi protein complex · an experimental structure of the same protein · chain A against D, TM-score 0.68
• 7SBF · PZM21 bound mu opioid receptor-gi protein complex · an experimental structure of the same protein · chain A against R, TM-score 0.68
• 6DDF · Mu Opioid Receptor-Gi Protein Complex · an experimental structure of the same protein · chain A against R, TM-score 0.68
• 6DDF · Mu opioid receptor-gi protein complex · an experimental structure of the same protein · chain A against R, TM-score 0.68
• 6DDE · Mu opioid receptor-gi protein complex · an experimental structure of the same protein · chain A against R, TM-score 0.68
• 4DKL · Crystal structure of the mu-opioid receptor bound to a morphinan antagonist · an experimental structure of the same protein · chain A against A, TM-score 0.67
• 4DKL · Crystal structure of the mu-opioid receptor bound to a morphinan antagonist · an experimental structure of the same protein · chain A against A, TM-score 0.67
• 7UL4 · Cryoem structure of inactive mor bound to alvimopan and MB6 · an experimental structure of the same protein · chain A against A, TM-score 0.66

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P42866
• Elsewhere: UniProt P42866 · AlphaFold DB P42866