MolNFT v1 · #188898 · protein

Cryoem structure of inactive mor bound to alvimopan and MB6

7UL4 · Mu-type opioid receptor: “Cryoem structure of inactive mor bound to alvimopan and MB6”. Electron microscopy, 1 ligand (NG0), 3 pockets (best druggability 0.71). MolNFT v1 #188898 on GenesisL1: 3D structure, binding sites and pockets…

PDB: 7UL4
Type: protein
Length: 351 residues
Chains: 2
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Mu-type opioid receptor; Megabody 6
UniProt: P42866
Ligands: NG0
Pockets: 3 · best druggability 0.71

Structure

electron microscopy · 2 distinct chains · 67% helix, 12% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Mu-type opioid receptor	protein	286	82% helix, 3% strand	P42866
D	Megabody 6	protein	65	0% helix, 51% strand	—

Ligands and binding sites

NG0 · N-[(2S)-2-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]methyl}-3-phenylpropanoyl]glycine · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	488	0.71	0.80	34	NG0
2	93	0.39	0.76	19	empty
3	83	0.35	0.76	20	empty

Interfaces

1 interface between chains.

A–D · 530 Å² buried · 9 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

7UL4 · CryoEM Structure of Inactive MOR Bound to Alvimopan and Mb6 · the same entry in another collection · chain A against A, TM-score 1.00
P42866 · AlphaFold monomer V2.0 prediction for mu-type opioid receptor (P42866) · a predicted model of the same protein · chain A against A, TM-score 0.91

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P42866
Elsewhere: RCSB PDB 7UL4 · PDBe 7UL4 · UniProt P42866

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.