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Cryoem structure of inactive mor bound to alvimopan and MB6
Analyse Cryoem structure of inactive mor bound to alvimopan and MB6 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7UL4
- Type
- protein
- Length
- 351 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Mu-type opioid receptor; Megabody 6
- UniProt
- P42866
- Ligands
- NG0
- Pockets
- 3 · best druggability 0.71
Structure
electron microscopy · 2 distinct chains · 67% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Mu-type opioid receptor | protein | 286 | 82% helix, 3% strand | P42866 |
| D | Megabody 6 | protein | 65 | 0% helix, 51% strand | — |
Ligands and binding sites
- NG0 · N-[(2S)-2-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]methyl}-3-phenylpropanoyl]glycine · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 488 | 0.71 | 0.80 | 34 | NG0 |
| 2 | 93 | 0.39 | 0.76 | 19 | empty |
| 3 | 83 | 0.35 | 0.76 | 20 | empty |
Interfaces
1 interface between chains.
- A–D · 530 Ų buried · 9 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P42866
- Elsewhere: RCSB PDB 7UL4 · PDBe 7UL4 · UniProt P42866
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