MolNFT v1 · #181255 · protein

Cryo-EM structure of full-length TRPV1 with capsaicin at 25 degrees celsius

7LPB: “Cryo-EM structure of full-length TRPV1 with capsaicin at 25 degrees celsius”. Electron microscopy, 4 ligands (6OU, LBN, YFP). MolNFT v1 #181255 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7LPB
Type: protein
Length: 2,384 residues
Chains: 4
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: O35433
Ligands: 6OU, LBN, YFP, 4DY

Structure

electron microscopy · 1 distinct chain.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D	—	protein	596	—	O35433

Ligands and binding sites

6OU · [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate · ligand · 12 copies · chains A, D, B, C
LBN · 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine · ligand · 8 copies · chains A, B, C, D
YFP · 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol · ligand · 4 copies · chains B, C, D, A
4DY · (6E)-N-(4-hydroxy-3-methoxybenzyl)-8-methylnon-6-enamide · ligand · 4 copies · chains A, D, B, C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

7LPB · Cryo-EM structure of full-length TRPV1 with capsaicin at 25 degrees Celsius · the same entry in another collection · chain A against A, TM-score 1.00
O35433 · AlphaFold monomer V2.0 prediction for transient receptor potential cation channel… · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O35433
Elsewhere: RCSB PDB 7LPB · PDBe 7LPB · UniProt O35433

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