Complex of novel maytansinoid M24 bound to T2R-ttl (two tubulin ALPHA/BETA heterodimers, RB3 stathmin-like domain, and tubulin tyrosine ligase)

Structure

x-ray diffraction · 6 distinct chains.

Ligands and binding sites

• GTP · Guanosine-5'-triphosphate · ligand · 2 copies · chains A, B, C, D
• GDP · Guanosine-5'-diphosphate · ligand · 2 copies · chains B, D
• XQ4 · (1S,2R,3S,5S,6S,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.1~10,14~.0~3, 5~]hexacosa-10(26),11,13,16,18-pentaen-6-yl (2S)-2-{methyl[3-(methylamino)propanoyl]amino}propanoate (non-preferred name) · ligand · chains D
• ACP · Phosphomethylphosphonic acid adenylate ester · ligand · chains F
• MG · Magnesium ion · metal · 5 copies · chains A, B, C, D, F
• CA · Calcium ion · metal · 4 copies · chains A, E, B, C
• CL · Chloride ion · ion · chains A
• EDO · 1,2-ethanediol · additive · 3 copies · chains A, E, B
• MES · 2-(N-morpholino)-ethanesulfonic acid · additive · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 7L05 · Complex of novel maytansinoid M24 bound to T2R-TTL (two tubulin alpha/beta heterodimers… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q2XVP4
• Every structure of UniProt P02554
• Every structure of UniProt P63043
• Every structure of UniProt E1BQ43
• Elsewhere: RCSB PDB 7L05 · PDBe 7L05 · UniProt Q2XVP4 · UniProt P02554 · UniProt P63043 · UniProt E1BQ43