UniProt Q2XVP4
Tubulin alpha-1B chain (Q2XVP4)
Tubulin alpha-1B chain (UniProt Q2XVP4): 195 experimental structures on GenesisL1, 72 ligands bound, 298 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q2XVP4
- Protein
- Tubulin alpha-1B chain
- Experimental structures
- 195
- Predicted models
- 0
- Ligands
- 72
- Pockets
- 298 · 24 records with a druggable one
Structures
195 records of Q2XVP4 in the MolNFT archive: 195 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3J8X | High-resolution structure of no-nucleotide kinesin on microtubules | electron microscopy | A | — | — |
| 3J8X | High-resolution structure of no-nucleotide kinesin on microtubules | electron microscopy | A | — | — |
| 3J8Y | High-resolution structure of ATP analog-bound kinesin on microtubules | electron microscopy | A | — | — |
| 3J8Y | High-resolution structure of ATP analog-bound kinesin on microtubules | electron microscopy | A | — | — |
| 3JAK | Cryo-EM structure of GTPgammaS-microtubule co-polymerized with EB3 (merged dataset with and without… | electron microscopy | E, J, C, L, A, K | — | — |
| 3JAK | Cryo-EM structure of gtpgammas-microtubule co-polymerized with EB3 (merged dataset with and without… | electron microscopy | E, J, C, L, A, K | — | — |
| 3JAL | Cryo-EM structure of GMPCPP-microtubule co-polymerized with EB3 | electron microscopy | E, J, C, L, A, K | — | — |
| 3JAL | Cryo-EM structure of gmpcpp-microtubule co-polymerized with EB3 | electron microscopy | E, J, C, L, A, K | — | — |
| 3JAR | Cryo-EM structure of GDP-microtubule co-polymerized with EB3 | electron microscopy | E, J, C, L, A, K | — | — |
| 3JAR | Cryo-EM structure of GDP-microtubule co-polymerized with EB3 | electron microscopy | E, J, C, L, A, K | — | — |
| 3JAS | Cryo-EM structure of dynamic GDP-microtubule (14 protofilaments) decorated with kinesin | electron microscopy | E, J, C, L, A, K | — | — |
| 3JAS | Cryo-EM structure of dynamic GDP-microtubule (14 protofilaments) decorated with kinesin | electron microscopy | E, J, C, L, A, K | — | — |
| 3JAT | Cryo-EM structure of GMPCPP-microtubule (14 protofilaments) decorated with kinesin | electron microscopy | E, J, C, L, A, K | — | — |
| 3JAT | Cryo-EM structure of gmpcpp-microtubule (14 protofilaments) decorated with kinesin | electron microscopy | E, J, C, L, A, K | — | — |
| 3JAW | Atomic model of a microtubule seam based on a cryo-EM reconstruction of the EB3-bound microtubule… | electron microscopy | A, C | — | — |
| 3JAW | Atomic model of a microtubule seam based on a cryo-EM reconstruction of the EB3-bound microtubule… | electron microscopy | A, C | — | — |
| 4ZHQ | Crystal structure of Tubulin-Stathmin-TTL-MMAE Complex | x-ray diffraction | A, C | GTP, MG, CA, 4Q5 | 15 (best 0.82) |
| 4ZHQ | Crystal structure of tubulin-stathmin-ttl-mmae complex | x-ray diffraction | A, C | — | — |
| 4ZI7 | Crystal structure of tubulin-stathmin-ttl-HTI286 complex | x-ray diffraction | A, C | — | — |
| 4ZOL | Crystal structure of tubulin-stathmin-ttl-tubulysin M complex | x-ray diffraction | A, C | — | — |
| 5CA0 | Crystal structure of T2R-ttl-lexibulin complex | x-ray diffraction | A, C | — | — |
| 5EZY | Crystal structure of T2R-TTL-taccalonolide AJ complex | x-ray diffraction | A, C | GTP, CA | — |
| 5EZY | Crystal structure of T2R-ttl-taccalonolide aj complex | x-ray diffraction | A, C | — | — |
| 5FNV | a new complex structure of tubulin with an alpha-beta unsaturated lactone | x-ray diffraction | A, C | GTP, CA, X3H | — |
| 5FNV | A new complex structure of tubulin with an alpha-beta unsaturated lactone | x-ray diffraction | A, C | — | — |
| 5H74 | Crystal structure of T2R-TTL-14b complex | x-ray diffraction | A, C | GTP, CA | — |
| 5H74 | Crystal structure of T2R-ttl-14B complex | x-ray diffraction | A, C | — | — |
| 5H7O | Crystal structure of DJ-101 in complex with tubulin protein | x-ray diffraction | A, C | GTP, MG, CA, 7Q7 | 16 (best 0.84) |
| 5H7O | Crystal structure of dj-101 in complex with tubulin protein | x-ray diffraction | A, C | — | — |
| 5JCB | Microtubule depolymerizing agent podophyllotoxin derivative YJTSF1 | x-ray diffraction | A, C | GTP, MG, CA, NV4, NA | — |
| 5JCB | Microtubule depolymerizing agent podophyllotoxin derivative YJTSF1 | x-ray diffraction | A, C | — | — |
| 5JQG | An apo tubulin-rb-ttl complex structure used for side-by-side comparison | x-ray diffraction | A, C | — | — |
| 5KMG | Near-atomic cryo-EM structure of PRC1 bound to the microtubule | electron microscopy | A | GTP, MG | — |
| 5KMG | Near-atomic cryo-EM structure of PRC1 bound to the microtubule | electron microscopy | A | GTP, MG | — |
| 5XIW | Crystal structure of T2R-ttl-colchicine complex | x-ray diffraction | A, C | GTP, CA, LOC | — |
| 5XKE | Crystal structure of T2R-ttl-demecolcine complex | x-ray diffraction | A, C | GTP, CA, LON | — |
| 5XKF | Crystal structure of T2R-ttl-MPC6827 complex | x-ray diffraction | A, C | GTP, CA, 88U | — |
| 5XKG | Crystal structure of T2R-ttl-CH1 complex | x-ray diffraction | A, C | GTP, MG, CA, 890 | — |
| 5XKH | Crystal structure of T2R-TTL-CF1 complex | x-ray diffraction | A, C | GTP, MG, CA, 89C | 15 (best 0.83) |
| 5XKH | Crystal structure of T2R-ttl-CF1 complex | x-ray diffraction | A, C | GTP, MG, CA, 89C | — |
| 5XP3 | Crystal structure of apo T2R-ttl | x-ray diffraction | A, C | GTP, CA | — |
| 5YL2 | Crystal structure of T2R-ttl-Y28 complex | x-ray diffraction | A, C | GTP, MG, CA, 8WU | — |
| 5YLJ | Crystal structure of T2R-ttl-millepachine complex | x-ray diffraction | A, C | GTP, CA, 8X0 | — |
| 5YLS | Crystal structure of T2R-TTL-Y50 complex | x-ray diffraction | A, C | GTP, CA, Y50, MG | — |
| 5YLS | Crystal structure of T2R-ttl-Y50 complex | x-ray diffraction | A, C | GTP, CA, Y50, MG | — |
| 5Z4U | Crystal structure of T2R-ttl complex with 7A3 | x-ray diffraction | A, C | GTP, MG, CA, 96C | — |
| 5ZXH | The structure of MT189-tubulin complex | x-ray diffraction | A, C | GTP, MG, CA, 9LX | — |
| 6AGK | The structure of ch-II-77-tubulin complex | x-ray diffraction | A, C | GTP, CA, 9WR | — |
| 6B0C | KLP10A-amppnp in complex with curved tubulin and a microtubule | electron microscopy | A, C | GTP, MG | — |
| 6B0I | Apo KLP10A in complex with a microtubule | electron microscopy | A | GTP, MG | — |
| 6B0L | KLP10A-amppnp in complex with a microtubule | electron microscopy | A | GTP, MG | — |
| 6BJC | TPX2_MINI decorated gmpcpp-microtubule | electron microscopy | A, C, E, J, L, K | GTP, MG | — |
| 6BR1 | Tubulin-RB3_SLD-TTL in complex with heterocyclic pyrimidine compound 4a | x-ray diffraction | A, C | GTP, CA, MG, E3Y | 16 (best 0.85) |
| 6BR1 | Tubulin-RB3_SLD-ttl in complex with heterocyclic pyrimidine compound 4A | x-ray diffraction | A, C | GTP, CA, MG, E3Y | — |
| 6BRF | Tubulin-RB3_SLD-ttl in complex with heterocyclic pyrimidine compound 4B | x-ray diffraction | A, C | GTP, CA, MG, E44 | — |
| 6BRY | Tubulin-RB3_SLD-ttl in complex with heterocyclic pyrimidine compound 6A | x-ray diffraction | A, C | GTP, MG, CA, GK9 | — |
| 6BS2 | Tubulin-RB3_SLD-ttl in complex with heterocyclic pyrimidine compound 8B | x-ray diffraction | A, C | GTP, CA, MG, E9Y | — |
| 6CVJ | Model of synthetic tau (four tandem repeats of first repeat sequence) bound to the microtubule | electron microscopy | A | GTP, MG, GDP | — |
| 6CVN | Model of synthetic tau (R2X4) bound to the microtubule | electron microscopy | B | GTP, MG, GDP | — |
| 6D88 | Tubulin-RB3_SLD-ttl in complex with compound 13F | x-ray diffraction | A, C | GTP, CA, MG, G9K | — |
135 records more on the page itself.
Ligands
- GTP · Guanosine-5'-triphosphate · in 165 records
- MG · Magnesium ion · in 152 records
- CA · Calcium ion · in 84 records
- GDP · Guanosine-5'-diphosphate · in 19 records
- CL · Chloride ion · in 18 records
- G2P · Phosphomethylphosphonic acid guanylate ester · in 6 records
- GSP · 5'-guanosine-diphosphate-monothiophosphate · in 4 records
- G2X · 6-[2,6-bis(fluoranyl)-4-[3-(methylamino) propoxy]phenyl]-5-chloranyl-N-[(2S)-1,1,1-tris(fluoranyl)propan-2-yl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine · in 3 records
- O9B · (2~{R})-1-methylpiperidine-2-carboxylic acid · in 3 records
- SO4 · Sulfate ion · in 3 records
- 89C · 4-[(4-methoxy-3-oxidanyl-phenyl)-methyl-amino]chromen-2-one · in 2 records
- DJ9 · 2-(1H-indol-6-yl)-4-(3,4,5-trimethoxyphenyl)-1H-imidazo[4,5-c]pyridine · in 2 records
- E3Y · 2-chloro-4-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl) pyrido[2,3-d]pyrimidine · in 2 records
- GDF · Vinorelbine · in 2 records
- H1F · 5-phenyl-3-(3,4,5-trimethoxyphenyl)-3,4-dihydropyrazole-2-carbothioamide · in 2 records
- HOS · Phomopsin A · in 2 records
- IC1 · 3-[(2,4,6-trimethoxy-phenyl)-methylene]-indolin-2-one · in 2 records
- J6L · 8,8-dimethyl-3-(2,4,5-trimethoxyphenyl)pyrano[2,3-f]chromen-4-one · in 2 records
- LOC · N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[d]heptalen-7-yl]ethanamide · in 2 records
- O9K · [(1~{R},3~{R})-1-(4-methanoyl-1,3-thiazol-2-yl)-4-methyl-3-(methylamino)pentyl] ethanoate · in 2 records
- P6S · benzyl hydrogen carbonate · in 2 records
- QW9 · [2-(4-methyl-1H-indol-3-yl)-1H-imidazol-5-yl](3,4,5-trimethoxyphenyl)methanone · in 2 records
- Y50 · E-3-(3-azanyl-4-methoxy-phenyl)-1-(5-methoxy-2,2-dimethyl-chromen-8-yl)prop-2-en-1-one · in 2 records
- Y5L · 4-(2-chloro-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)-7-methoxy-3,4-dihydroquinoxalin-2(1H)-one · in 2 records
- 4Q5 · N-methyl-L-valyl-N-[(3R,4S,5S)-1-{(2S)-2-[(1R,2R)-3-{[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]amino}-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl}-3-methoxy-5-methyl-1-oxoheptan-4-yl]-N-methyl-L-valinamide · in 1 record
- 7Q7 · 2-(1H-indol-4-yl)-4-(3,4,5-trimethoxyphenyl)-1H-imidazo[4,5-c]pyridine · in 1 record
- 88U · N-(4-methoxyphenyl)-N,2-dimethyl-quinazolin-4-amine · in 1 record
- 890 · 4-[(3-azanyl-4-methoxy-phenyl)-methyl-amino]chromen-2-one · in 1 record
- 8WU · (E)-1-(5-methoxy-2,2-dimethyl-chromen-8-yl)-3-(4-methoxy-3-oxidanyl-phenyl)prop-2-en-1-one · in 1 record
- 8X0 · (E)-1-(5-methoxy-2,2-dimethyl-chromen-8-yl)-3-(4-methoxyphenyl)prop-2-en-1-one · in 1 record
Elsewhere
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