444 in complex with tubulin

Structure

x-ray diffraction · 6 distinct chains.

Ligands and binding sites

• GTP · Guanosine-5'-triphosphate · ligand · 2 copies · chains A, B, C, D
• H0U · ~{N}-[5-(5-cyanothiophen-2-yl)-2-methyl-phenyl]-4-methyl-benzenesulfonamide · ligand · 2 copies · chains A, B, C, D
• GDP · Guanosine-5'-diphosphate · ligand · 2 copies · chains B, D
• ACP · Phosphomethylphosphonic acid adenylate ester · ligand · chains F
• MG · Magnesium ion · metal · 4 copies · chains A, B, C, F
• CA · Calcium ion · metal · 2 copies · chains A, C
• MES · 2-(N-morpholino)-ethanesulfonic acid · additive · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 7DBD · 444 in complex with tubulin · the same entry in another collection · chain C against C, TM-score 1.00
• P63042 · AlphaFold monomer V2.0 prediction for stathmin-4 (P63042) · a predicted model of the same protein · chain E against A, TM-score 0.77

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q2XVP4
• Every structure of UniProt A0A287AGU7
• Every structure of UniProt P63042
• Every structure of UniProt E1BQ43
• Elsewhere: RCSB PDB 7DBD · PDBe 7DBD · UniProt Q2XVP4 · UniProt A0A287AGU7 · UniProt P63042 · UniProt E1BQ43