UniProt A0A287AGU7
Tubulin beta chain (A0A287AGU7)
Tubulin beta chain (UniProt A0A287AGU7): 100 experimental structures on GenesisL1, 53 ligands bound, 211 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- A0A287AGU7
- Protein
- Tubulin beta chain
- Experimental structures
- 100
- Predicted models
- 0
- Ligands
- 53
- Pockets
- 211 · 16 records with a druggable one
Structures
100 records of A0A287AGU7 in the MolNFT archive: 100 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5XIW | Crystal structure of T2R-ttl-colchicine complex | x-ray diffraction | B, D | GTP, GDP, MG, LOC | — |
| 5XKF | Crystal structure of T2R-ttl-MPC6827 complex | x-ray diffraction | B, D | GDP, MG, 88U, GTP | — |
| 5XKG | Crystal structure of T2R-ttl-CH1 complex | x-ray diffraction | B, D | GDP, MG, 890, GTP | — |
| 5YL2 | Crystal structure of T2R-ttl-Y28 complex | x-ray diffraction | B, D | GDP, MG, 8WU, GTP | — |
| 5YLJ | Crystal structure of T2R-ttl-millepachine complex | x-ray diffraction | B, D | GTP, GDP, MG, 8X0 | — |
| 5YLS | Crystal structure of T2R-TTL-Y50 complex | x-ray diffraction | B, D | GDP, MG, Y50, GTP | — |
| 5YLS | Crystal structure of T2R-ttl-Y50 complex | x-ray diffraction | B, D | GDP, MG, Y50, GTP | — |
| 6BR1 | Tubulin-RB3_SLD-TTL in complex with heterocyclic pyrimidine compound 4a | x-ray diffraction | B, D | GTP, GDP, MG, E3Y | 13 (best 0.85) |
| 6BR1 | Tubulin-RB3_SLD-ttl in complex with heterocyclic pyrimidine compound 4A | x-ray diffraction | B, D | GTP, GDP, MG, E3Y | — |
| 6BRF | Tubulin-RB3_SLD-ttl in complex with heterocyclic pyrimidine compound 4B | x-ray diffraction | B, D | GDP, MG, E44, GTP | — |
| 6BRY | Tubulin-RB3_SLD-ttl in complex with heterocyclic pyrimidine compound 6A | x-ray diffraction | B, D | GDP, GK9, MG, GTP | — |
| 6BS2 | Tubulin-RB3_SLD-ttl in complex with heterocyclic pyrimidine compound 8B | x-ray diffraction | B, D | GTP, GDP, MG, E9Y | — |
| 6D88 | Tubulin-RB3_SLD-ttl in complex with compound 13F | x-ray diffraction | B, D | GDP, MG, G9K, GTP | — |
| 6KPP | BNC105 in complex with tubulin | x-ray diffraction | B, D | DO6, MG, GDP | — |
| 6LSM | Tubulin polymerization inhibitors | x-ray diffraction | B, D | GTP, GDP, MG, CA, ERX | — |
| 6LSN | Crystal structure of tubulin-inhibitor complex | x-ray diffraction | B, D | GTP, MG, GDP, CA, ERR | — |
| 6NNG | Tubulin-RB3_SLD-TTL in complex with compound DJ95 | x-ray diffraction | B, D | GTP, MG, GDP, DJ9 | — |
| 6NNG | Tubulin-RB3_SLD-ttl in complex with compound DJ95 | x-ray diffraction | B, D | GTP, MG, GDP, DJ9 | — |
| 6O5M | Tubulin-RB3_SLD-ttl in complex with compound 10BB | x-ray diffraction | B, D | GDP, MG, G8K, GTP | — |
| 6O5N | Tubulin-RB3_SLD-TTL in complex with compound 10ab | x-ray diffraction | B, D | GDP, MG, QW9, GTP | — |
| 6O5N | Tubulin-RB3_SLD-ttl in complex with compound 10AB | x-ray diffraction | B, D | GDP, MG, QW9, GTP | — |
| 6O61 | Tubulin-RB3_SLD-ttl in complex with compound abi-231 | x-ray diffraction | B, D | GDP, MG, KUM, GTP | — |
| 6PC4 | Tubulin-RB3_SLD-ttl in complex with compound abi-274 | x-ray diffraction | B, D | GDP, MG, O91, GTP | — |
| 6WWE | Apo KIF14[391-772] in complex with a microtubule | electron microscopy | B | GTP, GDP, TA1 | — |
| 6WWF | KIF14[391-772] - ADP in complex with a microtubule | electron microscopy | B | GTP, MG, GDP, TA1 | — |
| 6WWG | KIF14[391-772] dimer two-heads-bound state - ADP-AlFx in complex with a microtubule | electron microscopy | B, I | GTP, MG, GDP, TA1 | — |
| 6WWG | KIF14[391-772] dimer two-heads-bound state - ADP-alfx in complex with a microtubule | electron microscopy | B, I | GTP, MG, GDP, TA1 | — |
| 6WWH | KIF14[391-772] dimer two-heads-bound state - AMP-pnp in complex with a microtubule | electron microscopy | B, I | GTP, GDP, TA1 | — |
| 6WWI | Apo KIF14[391-755] in complex with a microtubule | electron microscopy | B | GTP, MG, GDP, TA1 | — |
| 6WWJ | KIF14[391-755] - ADP in complex with a microtubule | electron microscopy | B | GTP, GDP, TA1 | — |
| 6WWJ | KIF14[391-755] - ADP in complex with a microtubule | electron microscopy | B | GTP, GDP, TA1 | — |
| 6WWK | KIF14[391-755] dimer two-heads-bound state - ADP-alfx in complex with a microtubule | electron microscopy | B, I | GTP, MG, GDP, TA1 | — |
| 6WWL | KIF14[391-755] dimer two-heads-bound state - AMP-pnp in complex with a microtubule | electron microscopy | B, I | GTP, GDP, TA1 | — |
| 6WWM | KIF14[391-748] - ADP in complex with a microtubule | electron microscopy | B | GTP, GDP, TA1 | — |
| 6WWM | KIF14[391-748] - ADP in complex with a microtubule | electron microscopy | B | GTP, GDP, TA1 | — |
| 6WWN | KIF14[391-748] - ADP-alfx in complex with a microtubule | electron microscopy | B | GTP, GDP, TA1 | — |
| 6WWO | KIF14[391-748] - AMP-pnp in complex with a microtubule | electron microscopy | B | GTP, GDP, TA1 | — |
| 6WWP | Apo KIF14[391-743] in complex with a microtubule | electron microscopy | B | GTP, GDP, TA1 | — |
| 6WWQ | KIF14[391-743] - ADP in complex with a microtubule | electron microscopy | B | GTP, GDP, TA1 | — |
| 6WWR | Kif14[391-743] - ADP-AlFx open state class in complex with a microtubule | electron microscopy | B | GTP, GDP, TA1 | — |
| 6WWR | KIF14[391-743] - ADP-alfx open state class in complex with a microtubule | electron microscopy | B | GTP, GDP, TA1 | — |
| 6WWS | KIF14[391-743] - AMP-pnp open state class in complex with a microtubule | electron microscopy | B | GTP, MG, GDP, TA1 | — |
| 6WWT | Apo KIF14[391-735] in complex with a microtubule | electron microscopy | B | GTP, MG, GDP, TA1 | — |
| 6WWU | KIF14[391-735] - ADP-alfx in complex with a microtubule | electron microscopy | B | GTP, MG, GDP, TA1 | — |
| 6WWV | KIF14[391-735] - ANP-PNP in complex with a microtubule | electron microscopy | B | GTP, MG, GDP, TA1 | 10 (best 0.84) |
| 6WWV | KIF14[391-735] - anp-pnp in complex with a microtubule | electron microscopy | B | GTP, GDP, TA1 | — |
| 6X1C | Tubulin-RB3_SLD-ttl in complex with compound 5J | x-ray diffraction | B, D | GDP, MG, Y5J, GTP | — |
| 6X1E | Tubulin-RB3_SLD-TTL in complex with compound 5l | x-ray diffraction | B, D | GTP, GDP, MG, Y5L | — |
| 6X1E | Tubulin-RB3_SLD-ttl in complex with compound 5L | x-ray diffraction | B, D | GTP, GDP, MG, Y5L | — |
| 6X1F | Tubulin-RB3_SLD-ttl in complex with compound 5M | x-ray diffraction | B, D | GDP, MG, Y5M, GTP | — |
| 6XER | Tubulin-RB3_SLD in complex with colchicine | x-ray diffraction | B, D | GTP, SO4, GDP, LOC | — |
| 6XES | Tubulin-RB3_SLD in complex with compound 40a | x-ray diffraction | B, D | GTP, SO4, GDP, TU3 | 17 (best 0.86) |
| 6XES | Tubulin-RB3_SLD in complex with compound 40A | x-ray diffraction | B, D | GTP, SO4, GDP, TU3 | — |
| 6XET | Tubulin-RB3_SLD in complex with compound 60C | x-ray diffraction | B, D | GTP, SO4, GDP, TU2 | — |
| 7CDA | Crystal structure of T2R-ttl-pac complex | x-ray diffraction | B, D | GTP, MG, GDP, AEU | — |
| 7CE6 | Crystal structure of T2R-ttl-COMPOUND9 complex | x-ray diffraction | B, D | GTP, MG, GDP, AF6 | — |
| 7CE8 | Crystal structure of T2R-TTL-Compound11 complex | x-ray diffraction | B, D | GTP, MG, GDP, AEX | 14 (best 0.83) |
| 7CE8 | Crystal structure of T2R-ttl-COMPOUND11 complex | x-ray diffraction | B, D | GTP, MG, GDP, AEX | — |
| 7CEK | Crystal structure of T2R-ttl-bml-284 complex | x-ray diffraction | B, D | GTP, MG, GDP, CA, FW9, CL | — |
| 7CLD | Crystal structure of T2R-TTL-Cevipabulin complex | x-ray diffraction | B, D | GTP, MG, GDP, CA, G2X | 13 (best 0.84) |
40 records more on the page itself.
Ligands
- GDP · Guanosine-5'-diphosphate · in 100 records
- GTP · Guanosine-5'-triphosphate · in 98 records
- MG · Magnesium ion · in 71 records
- TA1 · Taxol · in 35 records
- CA · Calcium ion · in 20 records
- G2X · 6-[2,6-bis(fluoranyl)-4-[3-(methylamino) propoxy]phenyl]-5-chloranyl-N-[(2S)-1,1,1-tris(fluoranyl)propan-2-yl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine · in 4 records
- SO4 · Sulfate ion · in 4 records
- 6K9 · (1S,3S,6S,9S,12S,14R,16R,18S,20R,21R,22S,26R,29S,31R,32S,33R,35R,36S)-20-[(2S)-3-amino-2-hydroxypropyl]-21-methoxy-14-methyl-8,15-dimethylidene-2,19,30,34,37,39,40,41-octaoxanonacyclo[24.9.2.1~3,32~.1~3,33~.1~6,9~.1~12,16~.0~18,22~.0~29,36~.0~31,35~]hentetracontan-24-one (non-preferred name) · in 2 records
- AEX · N-butyl-9H-beta-carbolin-3-amine · in 2 records
- CL · Chloride ion · in 2 records
- DJ9 · 2-(1H-indol-6-yl)-4-(3,4,5-trimethoxyphenyl)-1H-imidazo[4,5-c]pyridine · in 2 records
- E3Y · 2-chloro-4-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl) pyrido[2,3-d]pyrimidine · in 2 records
- EPD · Epothilone D · in 2 records
- GDF · Vinorelbine · in 2 records
- H1C · methyl ~{N}-(5-butyl-1~{H}-benzimidazol-2-yl)carbamate · in 2 records
- H1F · 5-phenyl-3-(3,4,5-trimethoxyphenyl)-3,4-dihydropyrazole-2-carbothioamide · in 2 records
- H1O · 2-(1-methylindol-4-yl)-7-(3,4,5-trimethoxyphenyl)-1~{H}-benzimidazole · in 2 records
- HOS · Phomopsin A · in 2 records
- IC1 · 3-[(2,4,6-trimethoxy-phenyl)-methylene]-indolin-2-one · in 2 records
- LOC · N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[d]heptalen-7-yl]ethanamide · in 2 records
- QW9 · [2-(4-methyl-1H-indol-3-yl)-1H-imidazol-5-yl](3,4,5-trimethoxyphenyl)methanone · in 2 records
- TU3 · [6-(3-hydroxy-4-methylphenyl)pyrazin-2-yl](3,4,5-trimethoxyphenyl)methanone · in 2 records
- Y50 · E-3-(3-azanyl-4-methoxy-phenyl)-1-(5-methoxy-2,2-dimethyl-chromen-8-yl)prop-2-en-1-one · in 2 records
- Y5L · 4-(2-chloro-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)-7-methoxy-3,4-dihydroquinoxalin-2(1H)-one · in 2 records
- 88U · N-(4-methoxyphenyl)-N,2-dimethyl-quinazolin-4-amine · in 1 record
- 890 · 4-[(3-azanyl-4-methoxy-phenyl)-methyl-amino]chromen-2-one · in 1 record
- 8WU · (E)-1-(5-methoxy-2,2-dimethyl-chromen-8-yl)-3-(4-methoxy-3-oxidanyl-phenyl)prop-2-en-1-one · in 1 record
- 8X0 · (E)-1-(5-methoxy-2,2-dimethyl-chromen-8-yl)-3-(4-methoxyphenyl)prop-2-en-1-one · in 1 record
- AEU · N-[(3-phenoxyphenyl)methyl]-9H-beta-carbolin-3-amine · in 1 record
- AF6 · N-benzyl-9H-beta-carbolin-3-amine · in 1 record
Elsewhere
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