Tubulin-RB3_SLD-ttl in complex with heterocyclic pyrimidine compound 6A

Structure

x-ray diffraction · 6 distinct chains.

Ligands and binding sites

• GTP · Guanosine-5'-triphosphate · ligand · 2 copies · chains A, C, D
• GDP · Guanosine-5'-diphosphate · ligand · 2 copies · chains B, D
• GK9 · 1-(2-chlorofuro[3,2-d]pyrimidin-4-yl)-6-methoxy-1,2,3, 4-tetrahydroquinoline · ligand · 2 copies · chains A, B, C, D
• ACP · Phosphomethylphosphonic acid adenylate ester · ligand · chains F
• MG · Magnesium ion · metal · 4 copies · chains A, B, C, F
• CA · Calcium ion · metal · 2 copies · chains A, C
• MES · 2-(N-morpholino)-ethanesulfonic acid · additive · 3 copies · chains B, C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 6BRY · Tubulin-RB3_SLD-TTL in complex with heterocyclic pyrimidine compound 6a · the same entry in another collection · chain C against C, TM-score 1.00
• Q9H169 · AlphaFold monomer V2.0 prediction for stathmin-4 (Q9H169) · a predicted model of the same protein · chain E against A, TM-score 0.76

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q2XVP4
• Every structure of UniProt A0A287AGU7
• Every structure of UniProt Q9H169
• Every structure of UniProt E1BQ43
• Elsewhere: RCSB PDB 6BRY · PDBe 6BRY · UniProt Q2XVP4 · UniProt A0A287AGU7 · UniProt Q9H169 · UniProt E1BQ43