MolNFT v1 · #133804 · protein
Tubulin-maytansinoid-4A-complex
5SB9: “Tubulin-maytansinoid-4A-complex”. X-ray diffraction, 6 ligands (GTP, GDP, 5IX). MolNFT v1 #133804 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5SB9
- Type
- protein
- Length
- 2,153 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P81947, Q6B856, P63043, E1BQ43
- Ligands
- GTP, GDP, 5IX, ACP, MG, CA
Structure
x-ray diffraction · 6 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 437 | — | P81947 |
| B | — | protein | 424 | — | Q6B856 |
| C | — | protein | 440 | — | P81947 |
| D | — | protein | 421 | — | Q6B856 |
| E | — | protein | 123 | — | P63043 |
| F | — | protein | 308 | — | E1BQ43 |
Ligands and binding sites
- GTP · Guanosine-5'-triphosphate · ligand · 2 copies · chains A, B, C, D
- GDP · Guanosine-5'-diphosphate · ligand · 2 copies · chains B, D
- 5IX · (1S,2R,3S,5S,6S,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.1~10,14~.0~3, 5~]hexacosa-10(26),11,13,16,18-pentaen-6-yl phenylacetate · ligand · chains D
- ACP · Phosphomethylphosphonic acid adenylate ester · ligand · chains F
- MG · Magnesium ion · metal · 5 copies · chains A, B, C, D, F
- CA · Calcium ion · metal · 3 copies · chains A, E, C
- MES · 2-(N-morpholino)-ethanesulfonic acid · additive · chains A, B
- IMD · Imidazole · additive · chains C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P81947
- Every structure of UniProt Q6B856
- Every structure of UniProt P63043
- Every structure of UniProt E1BQ43
- Elsewhere: RCSB PDB 5SB9 · PDBe 5SB9 · UniProt P81947 · UniProt Q6B856 · UniProt P63043 · UniProt E1BQ43
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