(M)L214A mutant of the rhodobacter sphaeroides reaction center

Structure

x-ray diffraction · 3 distinct chains · 52% helix, 10% strand (DSSP).

Ligands and binding sites

• BCL · Bacteriochlorophyll A · ligand · 4 copies · chains L, M
• BPH · Bacteriopheophytin A · ligand · 2 copies · chains L, M
• U10 · Ubiquinone-10 · ligand · 2 copies · chains L, M
• HTO · Heptane-1,2,3-triol · ligand · chains L
• SPO · Spheroidene · ligand · chains M
• CDL · Cardiolipin · ligand · chains L, M, H
• PC1 · 1,2-diacyl-sn-glycero-3-phosphocholine · ligand · chains L, M
• GGD · Nonadec-10-enoic acid 2-[3,4-dihydroxy-6-hydroxymethyl-5-(3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-yloxy] -1-octadec-9-enoyloxymethyl-ethyl ester · ligand · chains L, M, H
• FE · Fe (III) ion · metal · chains L, M
• PO4 · Phosphate ion · ion · 5 copies · chains L, M, H
• GOL · Glycerol · additive · 11 copies · chains L, H, M
• LDA · Lauryl dimethylamine-N-oxide · additive · 3 copies · chains L, M, H

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

15 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.

Interfaces

3 interfaces between chains.

• L–M · 4463 Ų buried · 60 hydrogen bonds · protein-protein
• M–H · 2791 Ų buried · 42 hydrogen bonds · protein-protein
• L–H · 1601 Ų buried · 16 hydrogen bonds · protein-protein

Compared structures

• 4IN6 · (M)L214A mutant of the Rhodobacter sphaeroides Reaction Center · the same entry in another collection · chain L against L, TM-score 1.00

Analyse

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• Elsewhere: RCSB PDB 4IN6 · PDBe 4IN6 · UniProt P0C0Y8 · UniProt P0C0Y9 · UniProt P0C0Y7