Research workbench
Tubulin alpha-beta dimer, electron diffraction
Analyse Tubulin alpha-beta dimer, electron diffraction in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1TUB
- Type
- protein
- Length
- 867 residues
- Chains
- 2
- Method
- electron crystallography
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tubulin
- UniProt
- P02550, P02554
- Ligands
- GTP, GDP, TXL
- Pockets
- 17 · best druggability 0.83
Structure
electron crystallography · 2 distinct chains · 38% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tubulin | protein | 440 | 37% helix, 10% strand | P02550 |
| B | Tubulin | protein | 427 | 39% helix, 10% strand | P02554 |
Ligands and binding sites
- GTP · Guanosine-5'-triphosphate · ligand · chains A, B
- GDP · Guanosine-5'-diphosphate · ligand · chains B
- TXL · Taxotere · ligand · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
17 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 268 | 0.83 | 0.95 | 51 | GTP |
| 2 | 157 | 0.79 | 0.95 | 36 | empty |
| 3 | 193 | 0.66 | 0.85 | 34 | empty |
| 4 | 392 | 0.65 | 0.79 | 50 | TXL |
| 5 | 111 | 0.64 | 0.88 | 30 | empty |
Interfaces
1 interface between chains.
- A–B · 1710 Ų buried · 27 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 3 covalent (covalent ligand).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P02550
- Every structure of UniProt P02554
- Elsewhere: RCSB PDB 1TUB · PDBe 1TUB · UniProt P02550 · UniProt P02554
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