UniProt P02550
Tubulin alpha-1A chain (P02550)
Tubulin alpha-1A chain (UniProt P02550): 61 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 145 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P02550
- Protein
- Tubulin alpha-1A chain
- Experimental structures
- 61
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 145 · 10 records with a druggable one
Structures
62 records of P02550 in the MolNFT archive: 61 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1FFX | TUBULIN:STATHMIN-like domain complex | x-ray diffraction | A, C | — | — |
| 1FFX | TUBULIN:STATHMIN-like domain complex | x-ray diffraction | A, C | — | — |
| 1IA0 | KIF1A head-microtubule complex structure in ATP-form | electron microscopy | A | — | — |
| 1IA0 | KIF1A head-microtubule complex structure in ATP-form | electron microscopy | A | — | — |
| 1SA0 | Tubulin-colchicine: stathmin-like domain complex | x-ray diffraction | A, C | — | — |
| 1SA0 | Tubulin-colchicine: stathmin-like domain complex | x-ray diffraction | A, C | — | — |
| 1SA1 | Tubulin-podophyllotoxin: stathmin-like domain complex | x-ray diffraction | A, C | — | — |
| 1SA1 | Tubulin-podophyllotoxin: stathmin-like domain complex | x-ray diffraction | A, C | — | — |
| 1TUB | Tubulin alpha-beta dimer, electron diffraction | electron crystallography | A | — | — |
| 1TUB | Tubulin alpha-beta dimer, electron diffraction | electron crystallography | A | — | — |
| 1TVK | The binding mode of epothilone A on a,b-tubulin by electron crystallography | electron crystallography | A | — | — |
| 1TVK | The binding mode of epothilone a on A,B-tubulin by electron crystallography | electron crystallography | A | — | — |
| 2HXF | KIF1A head-microtubule complex structure in amppnp-form | electron microscopy | A | — | — |
| 2HXF | KIF1A head-microtubule complex structure in amppnp-form | electron microscopy | A | — | — |
| 2HXH | KIF1A head-microtubule complex structure in adp-form | electron microscopy | A | — | — |
| 2HXH | KIF1A head-microtubule complex structure in ADP-form | electron microscopy | A | — | — |
| 2WBE | Kinesin-5-Tubulin Complex with AMPPNP | electron microscopy | A | — | — |
| 2WBE | Kinesin-5-tubulin complex with amppnp | electron microscopy | A | — | — |
| 3EDL | Kinesin13-Microtubule Ring complex | electron microscopy | A, F | — | — |
| 3EDL | KINESIN13-microtubule ring complex | electron microscopy | A, F | — | — |
| 3J6E | Energy minimized average structure of Microtubules stabilized by GmpCpp | electron microscopy | A, C, E, G, I, K, M, O, Q | — | — |
| 3J6E | Energy minimized average structure of microtubules stabilized by gmpcpp | electron microscopy | A, C, E, G, I, K, M, O, Q | — | — |
| 3J6F | Minimized average structure of GDP-bound dynamic microtubules | electron microscopy | A, C, E, G, I, K, M, O, Q | — | — |
| 3J6F | Minimized average structure of GDP-bound dynamic microtubules | electron microscopy | A, C, E, G, I, K, M, O, Q | — | — |
| 3J6G | Minimized average structure of microtubules stabilized by taxol | electron microscopy | A, C, E, G, I, K, M, O, Q | — | — |
| 3J6G | Minimized average structure of microtubules stabilized by taxol | electron microscopy | A, C, E, G, I, K, M, O, Q | — | — |
| 3J6H | Nucleotide-free Kinesin motor domain complexed with GMPCPP-microtubule | electron microscopy | A | — | — |
| 3J6H | Nucleotide-free kinesin motor domain complexed with gmpcpp-microtubule | electron microscopy | A | — | — |
| 3J6P | Pseudo-atomic model of dynein microtubule binding domain-tubulin complex based on a cryoEM map | electron microscopy | A | — | — |
| 3J6P | Pseudo-atomic model of dynein microtubule binding domain-tubulin complex based on a cryoem MAP | electron microscopy | A | — | — |
| 3J7I | Structure of alpha- and beta- tubulin in GMPCPP-microtubules | electron microscopy | A | — | — |
| 3J7I | Structure of alpha- and beta- tubulin in gmpcpp-microtubules | electron microscopy | A | — | — |
| 5MM4 | Ustilago maydis kinesin-5 motor domain in the AMPPNP state bound to microtubules | electron microscopy | A | GTP, MG | — |
| 5MM4 | Ustilago maydis kinesin-5 motor domain in the amppnp state bound to microtubules | electron microscopy | A | GTP, MG | — |
| 5MM7 | Ustilago maydis kinesin-5 motor domain with N-terminal extension in the AMPPNP state bound to… | electron microscopy | A | GTP, MG | — |
| 5MM7 | Ustilago maydis kinesin-5 motor domain with N-terminal extension in the amppnp state bound to… | electron microscopy | A | GTP, MG | — |
| 5XXT | GDP-microtubule complexed with nucleotide-free KIF5C | electron microscopy | A, C, E, G, I, K, M, O, Q | GTP, MG, GDP | 20 (best 0.85) |
| 5XXT | GDP-microtubule complexed with nucleotide-free KIF5C | electron microscopy | A, C, E, G, I, K, M, O, Q | GTP, MG, GDP | — |
| 5XXV | GDP-microtubule complexed with KIF5C in AMPPNP state | electron microscopy | A, C, E, G, I, K, M, O, Q | MG, GTP, GDP | 20 (best 0.85) |
| 5XXV | GDP-microtubule complexed with KIF5C in amppnp state | electron microscopy | A, C, E, G, I, K, M, O, Q | MG, GTP, GDP | — |
| 5XXW | GDP-microtubule complexed with KIF5C in ATP state | electron microscopy | A, C, E, G, I, K, M, O, Q | GTP, MG, GDP | 20 (best 0.85) |
| 5XXW | GDP-microtubule complexed with KIF5C in ATP state | electron microscopy | A, C, E, G, I, K, M, O, Q | GTP, MG, GDP | — |
| 5XXX | GMPCPP-microtubule complexed with nucleotide-free KIF5C | electron microscopy | A, C, E, G, I, K, M, O, Q | GTP, MG | — |
| 5XXX | Gmpcpp-microtubule complexed with nucleotide-free KIF5C | electron microscopy | A, C, E, G, I, K, M, O, Q | GTP, MG | — |
| 6MLQ | Cryo-EM structure of microtubule-bound KIF7 in the ADP state | electron microscopy | A | MG, GTP | — |
| 6MLR | Cryo-EM structure of microtubule-bound Kif7 in the AMPPNP state | electron microscopy | A | GTP | — |
| 6MLR | Cryo-EM structure of microtubule-bound KIF7 in the amppnp state | electron microscopy | A | GTP | — |
| 6MZE | Structural Basis of Tubulin Recruitment and Assembly by Microtubule Polymerases with Tumor… | x-ray diffraction | A, C, H, J, O, Q, V, X | GTP, MG | — |
| 6MZE | Structural basis of tubulin recruitment and assembly by microtubule polymerases with tumor… | x-ray diffraction | A, C, H, J, O, Q, V, X | GTP, MG | — |
| 6MZF | Structural Basis of Tubulin Recruitment and Assembly by Microtubule Polymerases with Tumor… | x-ray diffraction | A, C, H, J, O, Q, V, X | GTP, MG | 17 (best 0.80) |
| 6MZF | Structural basis of tubulin recruitment and assembly by microtubule polymerases with tumor… | x-ray diffraction | A, C, H, J, O, Q, V, X | GTP, MG | — |
| 6MZG | Structural Basis of Tubulin Recruitment and Assembly by Microtubule Polymerases with Tumor… | x-ray diffraction | A, C, G, I | GTP, MG | 18 (best 0.83) |
| 6MZG | Structural basis of tubulin recruitment and assembly by microtubule polymerases with tumor… | x-ray diffraction | A, C, G, I | GTP, MG | — |
| 6VPO | Cryo-EM structure of microtubule-bound KLP61F motor domain in the AMPPNP state | electron microscopy | A | GTP, MG | — |
| 6VPO | Cryo-EM structure of microtubule-bound KLP61F motor domain in the amppnp state | electron microscopy | A | GTP, MG | — |
| 6VPP | Cryo-EM structure of microtubule-bound KLP61F motor with tail domain in the nucleotide-free state | electron microscopy | A | GTP, MG | 7 (best 0.83) |
| 6VPP | Cryo-EM structure of microtubule-bound KLP61F motor with tail domain in the nucleotide-free state | electron microscopy | A | GTP, MG | — |
| 7RS5 | Cryo-EM structure of Kip3 (AMPPNP) bound to Taxol-Stabilized Microtubules | electron microscopy | A, C, E, G, I, L, N, P, R | GTP, MG | 20 (best 0.84) |
| 7RX0 | Complex of AMPPNP-Kif7 and Gli2 Zinc-Finger domain bound to microtubules | electron microscopy | A | GTP | 8 (best 0.85) |
| 7RX0 | Complex of amppnp-KIF7 and GLI2 zinc-finger domain bound to microtubules | electron microscopy | A | GTP | — |
2 records more on the page itself.
Ligands
Experiment against prediction
- 6MZG chain G against the predicted model P02550: TM-score 0.99, RMSD 0.68 Å
- 6MZG chain G against the predicted model P02550: TM-score 0.99, RMSD 0.68 Å
- 6MZG chain A against the predicted model P02550: TM-score 0.99, RMSD 0.70 Å
- 6MZG chain A against the predicted model P02550: TM-score 0.99, RMSD 0.70 Å
- 6MZE chain A against the predicted model P02550: TM-score 0.99, RMSD 0.71 Å
- 6MZE chain A against the predicted model P02550: TM-score 0.99, RMSD 0.71 Å
- 6MZF chain J against the predicted model P02550: TM-score 0.99, RMSD 0.71 Å
- 6MZF chain X against the predicted model P02550: TM-score 0.99, RMSD 0.71 Å
- 6MZF chain H against the predicted model P02550: TM-score 0.99, RMSD 0.72 Å
- 6MZF chain Q against the predicted model P02550: TM-score 0.99, RMSD 0.72 Å
Elsewhere
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