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Galanin-bound galanin receptor 1 in complex with gi

Analyse Galanin-bound galanin receptor 1 in complex with gi in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
7WQ3
Type
protein
Length
1,160 residues
Chains
6
Method
electron microscopy
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt
P47211, P63096, P54311, P63212, P22466
Ligands
CLR

Structure

electron microscopy · 6 distinct chains.

ChainMoleculeTypeResiduesSecondary structureUniProt
R—protein289—P47211
A—protein225—P63096
B—protein339—P54311
G—protein58—P63212
S—protein233——
L—protein16—P22466

Ligands and binding sites

  • CLR · Cholesterol · ligand · 5 copies · chains R

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

  • 7WQ3 · Galanin-bound galanin receptor 1 in complex with Gi · the same entry in another collection · chain L against L, TM-score 1.00
  • P54311 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain B against A, TM-score 0.99
  • P47211 · AlphaFold monomer V2.0 prediction for galanin receptor type 1 (P47211) · a predicted model of the same protein · chain R against A, TM-score 0.92
  • P63096 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I) subunit… · a predicted model of the same protein · chain A against A, TM-score 0.81
  • P63212 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(O)… · a predicted model of the same protein · chain G against A, TM-score 0.67
  • P22466 · AlphaFold monomer V2.0 prediction for galanin peptides (P22466) · a predicted model of the same protein · chain L against A, TM-score 0.43

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