Research workbench
Pthrp-bound human PTH1R in complex with gs
Analyse Pthrp-bound human PTH1R in complex with gs in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7VVJ
- Type
- protein
- Length
- 1,154 residues
- Chains
- 6
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Guanine nucleotide-binding protein G(S) subunit alpha isoforms short; Guanine…
- UniProt
- P63092, P54311, P63212, P12272, Q03431
- Pockets
- 12 · best druggability 0.84
Structure
electron microscopy · 6 distinct chains · 37% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Guanine nucleotide-binding protein G(S) subunit alpha isoforms short | protein | 232 | 47% helix, 16% strand | P63092 |
| B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | protein | 339 | 9% helix, 44% strand | P54311 |
| G | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | protein | 57 | 54% helix, 0% strand | P63212 |
| N | Nanobody NB35 | protein | 128 | 5% helix, 45% strand | — |
| P | PTHRP[1-36] | protein | 32 | 91% helix, 0% strand | P12272 |
| R | Parathyroid HORMONE/PARATHYROID hormone-related peptide receptor | protein | 366 | 60% helix, 6% strand | Q03431 |
Pockets
12 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 897 | 0.84 | 0.86 | 79 | empty |
| 2 | 671 | 0.75 | 0.81 | 88 | empty |
| 3 | 820 | 0.72 | 0.77 | 61 | empty |
| 4 | 220 | 0.69 | 0.86 | 39 | empty |
| 5 | 857 | 0.68 | 0.75 | 51 | empty |
Interfaces
7 interfaces between chains.
- B–G · 2199 Ų buried · 16 hydrogen bonds · protein-protein
- P–R · 1809 Ų buried · 20 hydrogen bonds · protein-protein
- A–B · 1491 Ų buried · 20 hydrogen bonds · protein-protein
- A–R · 1366 Ų buried · 16 hydrogen bonds · protein-protein
- A–N · 874 Ų buried · 9 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 3 disulfide (disulfide).
Compared structures
- 7VVJ · PTHrP-bound human PTH1R in complex with Gs · the same entry in another collection · chain R against R, TM-score 1.00
- P54311 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain B against A, TM-score 1.00
- Q03431 · AlphaFold monomer V2.0 prediction for parathyroid HORMONE/PARATHYROID hormone-related… · a predicted model of the same protein · chain R against A, TM-score 0.93
- P12272 · AlphaFold monomer V2.0 prediction for parathyroid hormone-related protein (P12272) · a predicted model of the same protein · chain P against A, TM-score 0.80
- P63212 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(O)… · a predicted model of the same protein · chain G against A, TM-score 0.67
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P63092
- Every structure of UniProt P54311
- Every structure of UniProt P63212
- Every structure of UniProt P12272
- Every structure of UniProt Q03431
- Elsewhere: RCSB PDB 7VVJ · PDBe 7VVJ · UniProt P63092 · UniProt P54311 · UniProt P63212 · UniProt P12272 · UniProt Q03431
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