UniProt P12272
Parathyroid hormone-related protein (P12272)
Parathyroid hormone-related protein (UniProt P12272): 15 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 20 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P12272
- Protein
- Parathyroid hormone-related protein
- Experimental structures
- 15
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 20 · 7 records with a druggable one
Structures
16 records of P12272 in the MolNFT archive: 15 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1BZG | The solution structure of human parathyroid hormone-related protein (1-34) in near-physiological… | solution nmr | A | — | — |
| 1BZG | The solution structure of human parathyroid hormone-related protein (1-34) in near-physiological… | solution nmr | A | — | — |
| 1M5N | Crystal structure of HEAT repeats (1-11) of importin b bound to the non-classical NLS(67-94) of… | x-ray diffraction | Q | — | 4 (best 0.73) |
| 1M5N | Crystal structure of heat repeats (1-11) of importin B bound to the non-classical NLS(67-94) of… | x-ray diffraction | Q | — | 4 (best 0.73) |
| 3FFD | Structure of parathyroid hormone-related protein complexed to a neutralizing monoclonal antibody | x-ray diffraction | P | — | — |
| 3FFD | Structure of parathyroid hormone-related protein complexed to a neutralizing monoclonal antibody | x-ray diffraction | P | — | — |
| 3H3G | Crystal structure of the extracellular domain of the human parathyroid hormone receptor (PTH1R) in… | x-ray diffraction | B | — | 1 (best 0.54) |
| 3H3G | Crystal structure of the extracellular domain of the human parathyroid hormone receptor (PTH1R) in… | x-ray diffraction | B | NH2 | 1 (best 0.54) |
| 7UZO | Parathyroid hormone 1 receptor extracellular domain complexed with a peptide ligand containing one… | x-ray diffraction | B | ZN | — |
| 7VVJ | PTHrP-bound human PTH1R in complex with Gs | electron microscopy | P | — | 3 (best 0.69) |
| 7VVJ | Pthrp-bound human PTH1R in complex with gs | electron microscopy | P | — | 3 (best 0.69) |
| 8D51 | Parathyroid hormone 1 receptor extracellular domain complexed with a peptide ligand containing… | x-ray diffraction | B | ZN | — |
| 8D52 | Parathyroid hormone 1 receptor extracellular domain complexed with a peptide ligand containing… | x-ray diffraction | B | ZN | — |
| 8FLR | Human PTH1R in complex with PTHrP and Gs | electron microscopy | P | — | 2 (best 0.42) |
| 8HAF | PTHrP-PTH1R-Gs complex | electron microscopy | P | — | 2 (best 0.53) |
| P12272 | AlphaFold monomer V2.0 prediction for parathyroid hormone-related protein (P12272) | predicted | A | — | — |
Ligands
Experiment against prediction
- 8FLR chain P against the predicted model P12272: TM-score 0.84, RMSD 1.34 Å
- 7VVJ chain P against the predicted model P12272: TM-score 0.80, RMSD 1.01 Å
- 7VVJ chain P against the predicted model P12272: TM-score 0.80, RMSD 1.01 Å
- 8HAF chain P against the predicted model P12272: TM-score 0.75, RMSD 1.14 Å
- 3FFD chain P against the predicted model P12272: TM-score 0.69, RMSD 0.61 Å
- 3FFD chain P against the predicted model P12272: TM-score 0.69, RMSD 0.61 Å
- 7UZO chain B against the predicted model P12272: TM-score 0.60, RMSD 1.80 Å
- 3H3G chain B against the predicted model P12272: TM-score 0.59, RMSD 1.61 Å
- 3H3G chain B against the predicted model P12272: TM-score 0.59, RMSD 1.61 Å
- 8D52 chain B against the predicted model P12272: TM-score 0.49, RMSD 1.57 Å
Elsewhere
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