MolNFT v1 · #14321 · protein
Crystal structure of heat repeats (1-11) of importin B bound to the non-classical NLS(67-94) of pthrp
1M5N · Importin beta-1 subunit: “Crystal structure of heat repeats (1-11) of importin B bound to the non-classical NLS(67-94) of pthrp”. X-ray diffraction, 7 pockets (best druggability 0.73). MolNFT v1 #14321 on GenesisL1: 3D structure…
- PDB
- 1M5N
- Type
- protein
- Length
- 513 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Importin beta-1 subunit; Parathyroid hormone-related protein
- UniProt
- Q14974, P12272
- Pockets
- 7 · best druggability 0.73
Structure
x-ray diffraction · 2 distinct chains · 65% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| S | Importin beta-1 subunit | protein | 485 | 68% helix, 0% strand | Q14974 |
| Q | Parathyroid hormone-related protein | protein | 28 | 11% helix, 0% strand | P12272 |
Pockets
7 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 458 | 0.73 | 0.83 | 63 | empty |
| 2 | 184 | 0.54 | 0.79 | 25 | empty |
| 3 | 75 | 0.51 | 0.84 | 19 | empty |
| 4 | 56 | 0.50 | 0.86 | 12 | empty |
| 5 | 170 | 0.48 | 0.77 | 23 | empty |
Interfaces
1 interface between chains.
- S–Q · 1090 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 1M5N · Crystal structure of HEAT repeats (1-11) of importin b bound to the non-classical… · the same entry in another collection · chain S against S, TM-score 1.00
- Q14974 · AlphaFold monomer V2.0 prediction for importin subunit beta-1 (Q14974) · a predicted model of the same protein · chain S against A, TM-score 0.97
- P12272 · AlphaFold monomer V2.0 prediction for parathyroid hormone-related protein (P12272) · a predicted model of the same protein · chain Q against A, TM-score 0.22
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q14974
- Every structure of UniProt P12272
- Elsewhere: RCSB PDB 1M5N · PDBe 1M5N · UniProt Q14974 · UniProt P12272
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