UniProt Q03431
Parathyroid hormone/parathyroid hormone-related peptide receptor (Q03431)
Parathyroid hormone/parathyroid hormone-related peptide receptor (UniProt Q03431): 39 experimental structures on GenesisL1, 9 ligands bound, 96 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q03431
- Protein
- Parathyroid hormone/parathyroid hormone-related peptide receptor
- Experimental structures
- 39
- Predicted models
- 0
- Ligands
- 9
- Pockets
- 96 · 15 records with a druggable one
Structures
39 records of Q03431 in the MolNFT archive: 39 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1BL1 | Pth receptor N-terminus fragment, NMR, 1 structure | solution nmr | A | — | — |
| 1BL1 | Pth receptor N-terminus fragment, NMR, 1 structure | solution nmr | A | — | — |
| 3C4M | Structure of human parathyroid hormone in complex with the extracellular domain of its… | x-ray diffraction | A, B | — | — |
| 3C4M | Structure of human parathyroid hormone in complex with the extracellular domain of its… | x-ray diffraction | A, B | — | — |
| 3H3G | Crystal structure of the extracellular domain of the human parathyroid hormone receptor (PTH1R) in… | x-ray diffraction | A | — | — |
| 3H3G | Crystal structure of the extracellular domain of the human parathyroid hormone receptor (PTH1R) in… | x-ray diffraction | A | — | — |
| 3L2J | Dimeric structure of the ligand-free extracellular domain of the human parathyroid hormone receptor… | x-ray diffraction | A, B | — | — |
| 3L2J | Dimeric structure of the ligand-free extracellular domain of the human parathyroid hormone receptor… | x-ray diffraction | A, B | — | — |
| 6FJ3 | High resolution crystal structure of parathyroid hormone 1 receptor in complex with a peptide… | x-ray diffraction | A | NAG, FUC, OLA, CL | 8 (best 0.42) |
| 6FJ3 | High resolution crystal structure of parathyroid hormone 1 receptor in complex with a peptide… | x-ray diffraction | A | NH2, NAG, FUC, OLA, CL | — |
| 6NBF | Cryo-EM structure of parathyroid hormone receptor type 1 in complex with a long-acting parathyroid… | electron microscopy | R | CLR, PLM | — |
| 6NBF | Cryo-EM structure of parathyroid hormone receptor type 1 in complex with a long-acting parathyroid… | electron microscopy | R | CLR, PLM | — |
| 6NBH | Cryo-EM structure of parathyroid hormone receptor type 1 in complex with a long-acting parathyroid… | electron microscopy | R | CLR, PLM | — |
| 6NBI | Cryo-EM structure of parathyroid hormone receptor type 1 in complex with a long-acting parathyroid… | electron microscopy | R | CLR | — |
| 7UZP | parathyroid hormone 1 receptor extracellular domain complexed with a peptide ligand containing… | x-ray diffraction | A, C, E | — | 9 (best 0.76) |
| 7VVJ | Pthrp-bound human PTH1R in complex with gs | electron microscopy | R | — | — |
| 7VVK | PTH-bound human PTH1R in complex with Gs (class1) | electron microscopy | R | — | 5 (best 0.71) |
| 7VVK | Pth-bound human PTH1R in complex with gs (CLASS1) | electron microscopy | R | — | — |
| 7VVL | PTH-bound human PTH1R in complex with Gs (class2) | electron microscopy | R | — | 7 (best 0.70) |
| 7VVL | Pth-bound human PTH1R in complex with gs (CLASS2) | electron microscopy | R | — | — |
| 7VVM | PTH-bound human PTH1R in complex with Gs (class3) | electron microscopy | R | — | 4 (best 0.69) |
| 7VVM | Pth-bound human PTH1R in complex with gs (CLASS3) | electron microscopy | R | — | — |
| 7VVN | PTH-bound human PTH1R in complex with Gs (class4) | electron microscopy | R | — | — |
| 7VVN | Pth-bound human PTH1R in complex with gs (CLASS4) | electron microscopy | R | — | — |
| 7VVO | Pth-bound human PTH1R in complex with gs (CLASS5) | electron microscopy | R | — | — |
| 7Y35 | Cryo-EM structure of the Abaloparatide-bound human PTH1R-Gs complex | electron microscopy | R | — | 5 (best 0.72) |
| 7Y36 | Cryo-EM structure of the Teriparatide-bound human PTH1R-Gs complex | electron microscopy | R | — | 6 (best 0.76) |
| 8BIA | Crystal structure of Scribble PDZ1 with PTHR | x-ray diffraction | C | PO4 | — |
| 8D52 | Parathyroid hormone 1 receptor extracellular domain complexed with a peptide ligand containing… | x-ray diffraction | A | — | — |
| 8FLQ | Human PTH1R in complex with PTH(1-34) and Gs | electron microscopy | R | — | 6 (best 0.72) |
| 8FLR | Human PTH1R in complex with PTHrP and Gs | electron microscopy | R | — | 4 (best 0.74) |
| 8FLS | Human PTH1R in complex with Abaloparatide and Gs | electron microscopy | R | — | 6 (best 0.72) |
| 8FLU | Human PTH1R in complex with LA-PTH and Gs | electron microscopy | R | — | 5 (best 0.72) |
| 8GW8 | the human PTH1 receptor bound to an intracellular biased agonist | electron microscopy | R | KHF | 5 (best 0.78) |
| 8HA0 | Molecular recognition of two endogenous hormones by the human parathyroid hormone receptor-1 | electron microscopy | R | CLR, PLM | 6 (best 0.72) |
| 8HAF | PTHrP-PTH1R-Gs complex | electron microscopy | R | PLM, CLR | 7 (best 0.74) |
| 8JR9 | Small molecule agonist (PCO371) bound to human parathyroid hormone receptor type 1 (PTH1R) | electron microscopy | R | KHF | 5 (best 0.80) |
| 9JR2 | Cryo-EM structure of PTH-PTH1R-Gq (upright state) | electron microscopy | R | — | 8 (best 0.70) |
| Q03431 | AlphaFold monomer V2.0 prediction for parathyroid HORMONE/PARATHYROID hormone-related peptide… | — | — | — |
Ligands
- CLR · Cholesterol · in 6 records
- PLM · Palmitic acid · in 5 records
- CL · Chloride ion · in 2 records
- FUC · alpha-L-fucopyranose · in 2 records
- KHF · Pco-371 · in 2 records
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 2 records
- OLA · Oleic acid · in 2 records
- NH2 · Amino group · in 1 record
- PO4 · Phosphate ion · in 1 record
Experiment against prediction
- 3H3G chain A against the predicted model P0AEX9: TM-score 0.78, RMSD 0.64 Å
- 3C4M chain A against the predicted model P0AEX9: TM-score 0.79, RMSD 0.65 Å
- 3L2J chain A against the predicted model P0AEX9: TM-score 0.76, RMSD 0.63 Å
- 3C4M chain B against the predicted model P0AEX9: TM-score 0.78, RMSD 0.49 Å
Elsewhere
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