Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with C48/80, STATE1

Structure

electron microscopy · 5 distinct chains.

Ligands and binding sites

• CLR · Cholesterol · ligand · chains R
• 6IB · 2-[4-methoxy-3-[[2-methoxy-3-[[2-methoxy-5-[2-(methylamino)ethyl]phenyl]methyl]-5-[2-(methylamino) ethyl]phenyl]methyl]phenyl]-~{N}-methyl-ethanamine · ligand · chains R

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 7VV5 · Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with C48/80, state1 · the same entry in another collection · chain R against R, TM-score 1.00
• P62873 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain B against A, TM-score 1.00
• P59768 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(O)… · a predicted model of the same protein · chain G against A, TM-score 0.96
• Q96LB1 · AlphaFold monomer V2.0 prediction for mas-related G-protein coupled receptor member X2… · a predicted model of the same protein · chain R against A, TM-score 0.94
• P63096 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I) subunit… · a predicted model of the same protein · chain A against A, TM-score 0.83

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P63096
• Every structure of UniProt P62873
• Every structure of UniProt P59768
• Every structure of UniProt Q96LB1
• Elsewhere: RCSB PDB 7VV5 · PDBe 7VV5 · UniProt P63096 · UniProt P62873 · UniProt P59768 · UniProt Q96LB1