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Cryo-EM structure of the CCL15(26-92) bound CCR1-gi complex

Analyse Cryo-EM structure of the CCL15(26-92) bound CCR1-gi complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
7VL9
Type
protein
Length
1,214 residues
Chains
6
Method
electron microscopy
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt
P63096, P62873, P59768, Q16663, P32246
Ligands
CLR

Structure

electron microscopy · 6 distinct chains.

ChainMoleculeTypeResiduesSecondary structureUniProt
A—protein218—P63096
B—protein339—P62873
G—protein58—P59768
L—protein65—Q16663
R—protein302—P32246
S—protein232——

Ligands and binding sites

  • CLR · Cholesterol · ligand · chains R

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

  • 7VL9 · Cryo-EM structure of the CCL15(26-92) bound CCR1-Gi complex · the same entry in another collection · chain S against S, TM-score 1.00
  • P62873 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain B against A, TM-score 1.00
  • P59768 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(O)… · a predicted model of the same protein · chain G against A, TM-score 0.97
  • P32246 · AlphaFold monomer V2.0 prediction for C-C chemokine receptor type 1 (P32246) · a predicted model of the same protein · chain R against A, TM-score 0.93
  • Q16663 · AlphaFold monomer V2.0 prediction for C-C motif chemokine 15 (Q16663) · a predicted model of the same protein · chain L against A, TM-score 0.87
  • P63096 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I) subunit… · a predicted model of the same protein · chain A against A, TM-score 0.82

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