An agonist and pam-bound class a GPCR with gi protein complex structure

Structure

electron microscopy · 5 distinct chains.

Ligands and binding sites

• IXO · 4-(4,5-dihydro-1,2-oxazol-3-yloxy)-N,N,N-trimethylbut-2-yn-1-aminium · ligand · chains R
• 2CU · 3-amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methylpiperazin-1-yl)-2-oxoethoxy]thieno[2,3-b]pyridine-2-carboxamide · ligand · chains R

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 7V68 · An Agonist and PAM-bound Class A GPCR with Gi protein complex structure · the same entry in another collection · chain R against R, TM-score 1.00
• P62873 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain B against A, TM-score 0.99
• P59768 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(O)… · a predicted model of the same protein · chain C against A, TM-score 0.93
• P08173 · AlphaFold monomer V2.0 prediction for muscarinic acetylcholine receptor M4 (P08173) · a predicted model of the same protein · chain R against A, TM-score 0.92
• P63096 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I) subunit… · a predicted model of the same protein · chain A against A, TM-score 0.83

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P63096
• Every structure of UniProt P62873
• Every structure of UniProt P59768
• Every structure of UniProt P08173
• Elsewhere: RCSB PDB 7V68 · PDBe 7V68 · UniProt P63096 · UniProt P62873 · UniProt P59768 · UniProt P08173