UniProt P08173
Muscarinic acetylcholine receptor M4 (P08173)
Muscarinic acetylcholine receptor M4 (UniProt P08173): 26 experimental structures and 1 predicted model on GenesisL1, 18 ligands bound, 79 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P08173
- Protein
- Muscarinic acetylcholine receptor M4
- Experimental structures
- 26
- Predicted models
- 1
- Ligands
- 18
- Pockets
- 79 · 16 records with a druggable one
Structures
27 records of P08173 in the MolNFT archive: 26 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5DSG | Structure of the M4 muscarinic acetylcholine receptor (M4-mT4L) bound to tiotropium | x-ray diffraction | A, B | 0HK, OLA, EDT | — |
| 5DSG | Structure of the M4 muscarinic acetylcholine receptor (M4-MT4L) bound to tiotropium | x-ray diffraction | A, B | — | — |
| 6D9H | Cryo-EM structure of the human adenosine A1 receptor-Gi2-protein complex bound to its endogenous… | electron microscopy | R | ADN | 4 (best 0.76) |
| 6D9H | Cryo-EM structure of the human adenosine A1 receptor-GI2-protein complex bound to its endogenous… | electron microscopy | R | ADN | — |
| 6KP6 | The structural study of mutation induced inactivation of Human muscarinic receptor M4 | x-ray diffraction | A | — | — |
| 6KP6 | The structural study of mutation induced inactivation of human muscarinic receptor M4 | x-ray diffraction | A | — | — |
| 7LD3 | Cryo-EM structure of the human adenosine A1 receptor-Gi2-protein complex bound to its endogenous… | electron microscopy | R | ADN, XTD | 5 (best 0.74) |
| 7LD3 | Cryo-EM structure of the human adenosine A1 receptor-GI2-protein complex bound to its endogenous… | electron microscopy | R | ADN, XTD | — |
| 7LD4 | Cryo-EM structure of the human adenosine A1 receptor-Gi2-protein complex bound to its endogenous… | electron microscopy | R | ADN | 5 (best 0.79) |
| 7LD4 | Cryo-EM structure of the human adenosine A1 receptor-GI2-protein complex bound to its endogenous… | electron microscopy | R | ADN | — |
| 7TRP | Human M4 muscarinic acetylcholine receptor complex with Gi1 and the agonist iperoxo and positive… | electron microscopy | R | IUE, IXO | 5 (best 0.78) |
| 7TRQ | Human M4 muscarinic acetylcholine receptor complex with Gi1 and the agonist iperoxo and positive… | electron microscopy | R | IXO, IUI | 4 (best 0.78) |
| 7TRS | Human M4 muscarinic acetylcholine receptor complex with Gi1 and the endogenous agonist acetylcholine | electron microscopy | R | ACH | 4 (best 0.78) |
| 7V68 | An Agonist and PAM-bound Class A GPCR with Gi protein complex structure | electron microscopy | R | IXO, 2CU | 6 (best 0.82) |
| 7V68 | An agonist and pam-bound class a GPCR with gi protein complex structure | electron microscopy | R | IXO, 2CU | — |
| 7V69 | Cryo-EM structure of a class A GPCR-G protein complex | electron microscopy | R | — | 6 (best 0.77) |
| 7V69 | Cryo-EM structure of a class a GPCR-G protein complex | electron microscopy | R | — | — |
| 7V6A | Cry-EM structure of M4-c110-G protein complex | electron microscopy | R | 5XI | 8 (best 0.78) |
| 7V6A | Cry-EM structure of M4-C110-G protein complex | electron microscopy | R | 5XI | — |
| 8E9X | CryoEM structure of miniGo-coupled hM4Di in complex with DCZ | electron microscopy | A | WEC | 3 (best 0.80) |
| 8FX5 | Human M4 muscarinic acetylcholine receptor complex with Gi1 and xanomeline | electron microscopy | R | XNO | 3 (best 0.81) |
| 8IY9 | Structure of Niacin-GPR109A-G protein complex | electron microscopy | R | NIO | 6 (best 0.72) |
| 8IYH | Structure of MK6892-GPR109A-G-protein complex | electron microscopy | D | FI7 | 5 (best 0.82) |
| 8IYW | Structure of GSK256073-GPR109A-G-protein complex | electron microscopy | R | OKL | 7 (best 0.81) |
| 8JER | Structure of Acipimox-GPR109A-G protein complex | electron microscopy | R | OJX | 5 (best 0.77) |
| 8JHN | Structure of MMF-GPR109A-G protein complex | electron microscopy | D | UR9 | 3 (best 0.84) |
| P08173 | AlphaFold monomer V2.0 prediction for muscarinic acetylcholine receptor M4 (P08173) | predicted | A | — | — |
Ligands
- ADN · Adenosine · in 6 records
- IXO · 4-(4,5-dihydro-1,2-oxazol-3-yloxy)-N,N,N-trimethylbut-2-yn-1-aminium · in 4 records
- 2CU · 3-amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methylpiperazin-1-yl)-2-oxoethoxy]thieno[2,3-b]pyridine-2-carboxamide · in 2 records
- 5XI · methyl 4-[4-(3-methyl-2-oxidanylidene-benzimidazol-1-yl)piperidin-1-yl]piperidine-1-carboxylate · in 2 records
- XTD · {2-amino-4-[3,5-bis(trifluoromethyl)phenyl]thiophen-3-yl}(4-chlorophenyl)methanone · in 2 records
- 0HK · (1R,2R,4S,5S,7S)-7-{[hydroxy(dithiophen-2-yl)acetyl]oxy}-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.0~2,4~]nonane · in 1 record
- ACH · Acetylcholine · in 1 record
- EDT · {[-(bis-carboxymethyl-amino)-ethyl]-carboxymethyl-amino}-acetic acid · in 1 record
- FI7 · 2-[[2,2-dimethyl-3-[3-(5-oxidanylpyridin-2-yl)-1,2,4-oxadiazol-5-yl]propanoyl]amino]cyclohexene-1-carboxylic acid · in 1 record
- IUE · 3-amino-5-chloro-N-cyclopropyl-6-methoxy-4-methylthieno[2,3-b]pyridine-2-carboxamide · in 1 record
- IUI · 5-amino-3,4-dimethyl-N-{[4-(trifluoromethanesulfonyl)phenyl]methyl}thieno[2,3-c]pyridazine-6-carboxamide · in 1 record
- NIO · Nicotinic acid · in 1 record
- OJX · 5-methyl-4-oxidanyl-pyrazin-4-ium-2-carboxylic acid · in 1 record
- OKL · 8-chloranyl-3-pentyl-7H-purine-2,6-dione · in 1 record
- OLA · Oleic acid · in 1 record
- UR9 · Monomethyl fumarate · in 1 record
- WEC · 11-(4-methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine · in 1 record
- XNO · xanomeline · in 1 record
Experiment against prediction
- 8IY9 chain R against the predicted model Q8TDS4: TM-score 0.95, RMSD 1.55 Å
- 8IYH chain D against the predicted model Q8TDS4: TM-score 0.95, RMSD 1.55 Å
- 8JER chain R against the predicted model Q8TDS4: TM-score 0.95, RMSD 1.58 Å
- 8JHN chain D against the predicted model Q8TDS4: TM-score 0.94, RMSD 1.73 Å
- 8IYW chain R against the predicted model Q8TDS4: TM-score 0.94, RMSD 1.75 Å
- 8FX5 chain R against the predicted model P08173: TM-score 0.94, RMSD 1.96 Å
- 7TRS chain R against the predicted model P08173: TM-score 0.94, RMSD 1.96 Å
- 7TRQ chain R against the predicted model P08173: TM-score 0.93, RMSD 2.02 Å
- 7TRP chain R against the predicted model P08173: TM-score 0.93, RMSD 2.03 Å
- 7V69 chain R against the predicted model P08173: TM-score 0.93, RMSD 2.12 Å
Elsewhere
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