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Ligand · WEC

WEC · 11-(4-methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine

WEC, 11-(4-methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine (C18 H20 N4, 292.4 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (2 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds…

Component
WEC
Formula
C18 H20 N4
Class
ligand
Structures
2
PDB entries
2

Binding sites

WEC in 2 structures; the first of them:

  • 8E9W · CryoEM structure of miniGq-coupled hM3Dq in complex with DCZ · WEC A601 · binds ASP148, CYS149, SER152, ASN153, TRP200, LEU226, THR232, ALA236 and 9 more
  • 8E9X · CryoEM structure of miniGo-coupled hM4Di in complex with DCZ · WEC A501 · binds ASP112, CYS113, SER116, ASN117, TRP164, PHE189, LEU190, THR196 and 11 more

Residues it binds most

TYR 2, ASN 2, CYS 2, TRP 2, PHE 2, THR 2, ALA 2, ASP 2, GLY 2, LEU 2 (residue and the binding sites it lines).

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