Ligand · 2CU
2CU · 3-amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methylpiperazin-1-yl)-2-oxoethoxy]thieno[2,3-b]pyridine-2-carboxamide
2CU, 3-amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methylpiperazin-1-yl)-2-oxoethoxy]thieno[2,3-b]pyridine-2-carboxamide (C19 H24 Cl N5 O3 S, 437.9 g/mol), in the MolNFT structures on GenesisL1: bound in 7 records (5 PDB entries). Every…
- Component
- 2CU
- Formula
- C19 H24 Cl N5 O3 S
- Class
- ligand
- Structures
- 7
- PDB entries
- 5
Binding sites
2CU in 7 structures; the first of them:
- 6OIK · Muscarinic acetylcholine receptor 2-Go complex · 2CU R502 · binds TYR80, TYR83, THR84, TYR177, ILE178, PHE181, ASN419, TRP422 and 2 more
- 6U1N · GPCR-Beta arrestin structure in lipid bilayer · 2CU R601 · binds TYR80, TYR83, THR84, GLY87, TYR104, GLU175, CYS176, TYR177 and 8 more
- 7T94 · Cryo-EM structure of S1 state ACh-bound M2R-Go signaling complex with a PAM · 2CU A502 · binds TYR80, TYR83, TYR177, ILE178, PHE181, ASN410, ASN419, THR420 and 3 more
- 7T96 · Cryo-EM structure of S2 state ACh-bound M2R-Go signaling complex with a PAM · 2CU A502 · binds TYR80, TYR83, TYR177, ILE178, PHE181, ASN410, ASN419, TRP422 and 2 more
- 6OIK · Muscarinic acetylcholine receptor 2-go complex · 2CU R502 · binds TYR80, TYR83, THR84, TYR177, PHE181, ASN419, TRP422, THR423
- 6U1N · GPCR-beta arrestin structure in lipid bilayer · 2CU R601 · binds TYR80, TYR83, THR84, GLY87, GLU175, CYS176, TYR177, ILE178 and 6 more
- 7V68 · An agonist and pam-bound class a GPCR with gi protein complex structure · 2CU R502 · binds TYR89, TYR92, PHE186, ILE187, LEU190, SER191, ASN423, CYS426 and 6 more
Residues it binds most
TYR 7, ASN 7, THR 7, PHE 7, TRP 7, ILE 6, CYS 3, ALA 2, GLU 2, GLY 2 (residue and the binding sites it lines).
Found with
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