MolNFT v2 · #195163 · protein
Cryo-EM structure of S1 state ACh-bound M2R-Go signaling complex with a PAM
7T94: “Cryo-EM structure of S1 state ACh-bound M2R-Go signaling complex with a PAM”. Electron microscopy at 3.16, 2 ligands (ACH, 2CU). MolNFT v2 #195163 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7T94
- Type
- protein
- Length
- 1,113 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 3.16
- Source
- Homo sapiens; Mus musculus
- UniProt
- P08172, P09471, P62873, P59768
- Ligands
- ACH, 2CU
Structure
electron microscopy · resolution 3.16 · 5 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 265 | — | P08172 |
| B | — | protein | 218 | — | P09471 |
| C | — | protein | 338 | — | P62873 |
| D | — | protein | 56 | — | P59768 |
| E | — | protein | 236 | — | — |
Ligands and binding sites
- ACH · Acetylcholine · ligand · chains A
- 2CU · 3-amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methylpiperazin-1-yl)-2-oxoethoxy]thieno[2,3-b]pyridine-2-carboxamide · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- P62873 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain C against A, TM-score 0.99
- P08172 · AlphaFold monomer V2.0 prediction for muscarinic acetylcholine receptor M2 (P08172) · a predicted model of the same protein · chain A against A, TM-score 0.92
- P59768 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(O)… · a predicted model of the same protein · chain D against A, TM-score 0.87
- P09471 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(O) subunit… · a predicted model of the same protein · chain B against A, TM-score 0.77
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P08172
- Every structure of UniProt P09471
- Every structure of UniProt P62873
- Every structure of UniProt P59768
- Elsewhere: RCSB PDB 7T94 · PDBe 7T94 · UniProt P08172 · UniProt P09471 · UniProt P62873 · UniProt P59768
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