UniProt P09471
Guanine nucleotide-binding protein G(o) subunit alpha (P09471)
Guanine nucleotide-binding protein G(o) subunit alpha (UniProt P09471): 23 experimental structures and 1 predicted model on GenesisL1, 55 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P09471
- Protein
- Guanine nucleotide-binding protein G(o) subunit alpha
- Experimental structures
- 23
- Predicted models
- 1
- Pockets
- 55 · 9 records with a druggable one
Structures
24 records of P09471 in the MolNFT archive: 23 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6FUF | Crystal structure of the rhodopsin-mini-go complex | x-ray diffraction | B | — | — |
| 6G79 | Coupling specificity of heterotrimeric go to the serotonin 5-HT1B receptor | electron microscopy | A | — | — |
| 6K41 | Cryo-EM structure of ALPHA2BAR-goa complex | electron microscopy | A | — | — |
| 6OIK | Muscarinic acetylcholine receptor 2-go complex | electron microscopy | A | — | — |
| 6WWZ | Cryo-EM structure of the human chemokine receptor CCR6 in complex with CCL20 and a go protein | electron microscopy | A | — | — |
| 7EJ0 | Structure of the ALPHA2A-adrenergic receptor goa signaling complex | electron microscopy | A | — | — |
| 7EJ8 | Structure of the alpha2A-adrenergic receptor GoA signaling complex bound to brimonidine | electron microscopy | A | — | — |
| 7EJ8 | Structure of the ALPHA2A-adrenergic receptor goa signaling complex bound to brimonidine | electron microscopy | A | — | — |
| 7EJA | Structure of the ALPHA2A-adrenergic receptor goa signaling complex bound to dexmedetomidine | electron microscopy | A | — | — |
| 7EJK | Structure of the ALPHA2A-adrenergic receptor goa signaling complex bound to oxymetazoline | electron microscopy | A | — | — |
| 7QVM | Human oxytocin receptor (otr) oxytocin gq chimera (mgoqi) complex | electron microscopy | A | — | — |
| 7T90 | Cryo-EM structure of ACh-bound M2R-Go signaling complex in S2 state | electron microscopy | B | — | — |
| 7T94 | Cryo-EM structure of S1 state ACh-bound M2R-Go signaling complex with a PAM | electron microscopy | B | — | — |
| 7W2Z | Cryo-EM structure of the ghrelin-bound human ghrelin receptor-go complex | electron microscopy | A | — | — |
| 7W7E | Cryo-EM structure of the alpha2A adrenergic receptor GoA signaling complex bound to a biased agonist | electron microscopy | A | — | 7 (best 0.82) |
| 8E9X | CryoEM structure of miniGo-coupled hM4Di in complex with DCZ | electron microscopy | B | — | 4 (best 0.82) |
| 8FN1 | CryoEM structure of Go-coupled NTSR1 | electron microscopy | B | — | 5 (best 0.82) |
| 8HPT | Structure of C5a-pep bound mouse C5aR1 in complex with Go | electron microscopy | B | — | 8 (best 0.80) |
| 8I95 | Structure of EP54-C3aR-Go complex | electron microscopy | A | — | 5 (best 0.82) |
| 8I97 | Structure of Apo-C3aR-Go complex (Glacios) | electron microscopy | A | — | 5 (best 0.81) |
| 8IY9 | Structure of Niacin-GPR109A-G protein complex | electron microscopy | A | — | 8 (best 0.82) |
| 8IYW | Structure of GSK256073-GPR109A-G-protein complex | electron microscopy | B | — | 6 (best 0.81) |
| 8JZZ | Structure of human C5a-desArg bound human C5aR1 in complex with Go | electron microscopy | C | — | 7 (best 0.81) |
| P09471 | AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(O) subunit alpha (P09471) | predicted | A | — | — |
Experiment against prediction
- 6FUF chain B against the predicted model P09471: TM-score 0.88, RMSD 2.14 Å
- 8HPT chain B against the predicted model P09471: TM-score 0.79, RMSD 2.62 Å
- 8I97 chain A against the predicted model P09471: TM-score 0.78, RMSD 2.72 Å
- 8I95 chain A against the predicted model P09471: TM-score 0.78, RMSD 2.88 Å
- 7T90 chain B against the predicted model P09471: TM-score 0.78, RMSD 3.05 Å
- 6K41 chain A against the predicted model P09471: TM-score 0.78, RMSD 2.82 Å
- 8JZZ chain C against the predicted model P09471: TM-score 0.78, RMSD 2.87 Å
- 6OIK chain A against the predicted model P09471: TM-score 0.78, RMSD 2.92 Å
- 8IY9 chain A against the predicted model P09471: TM-score 0.77, RMSD 2.81 Å
- 7T94 chain B against the predicted model P09471: TM-score 0.77, RMSD 3.06 Å
Elsewhere
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