UniProt P08172
Muscarinic acetylcholine receptor M2 (P08172)
Muscarinic acetylcholine receptor M2 (UniProt P08172): 27 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 41 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P08172
- Protein
- Muscarinic acetylcholine receptor M2
- Experimental structures
- 27
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 41 · 11 records with a druggable one
Structures
28 records of P08172 in the MolNFT archive: 27 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3UON | Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist | x-ray diffraction | A | — | — |
| 3UON | Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist | x-ray diffraction | A | — | — |
| 4MQS | Structure of active human M2 muscarinic acetylcholine receptor bound to the agonist iperoxo | x-ray diffraction | A | — | — |
| 4MQS | Structure of active human M2 muscarinic acetylcholine receptor bound to the agonist iperoxo | x-ray diffraction | A | — | — |
| 4MQT | Structure of active human M2 muscarinic acetylcholine receptor bound to the agonist iperoxo and… | x-ray diffraction | A | — | — |
| 4MQT | Structure of active human M2 muscarinic acetylcholine receptor bound to the agonist iperoxo and… | x-ray diffraction | A | — | — |
| 5YC8 | Crystal structure of rationally thermostabilized M2 muscarinic acetylcholine receptor bound with… | x-ray diffraction | A | 3C0, HG | 6 (best 0.82) |
| 5YC8 | Crystal structure of rationally thermostabilized M2 muscarinic acetylcholine receptor bound with… | x-ray diffraction | A | 3C0, HG | — |
| 5ZK3 | Crystal structure of rationally thermostabilized M2 muscarinic acetylcholine receptor bound with QNB | x-ray diffraction | A | QNB | 2 (best 0.75) |
| 5ZK3 | Crystal structure of rationally thermostabilized M2 muscarinic acetylcholine receptor bound with qnb | x-ray diffraction | A | QNB | — |
| 5ZK8 | Crystal structure of M2 muscarinic acetylcholine receptor bound with NMS | x-ray diffraction | A | 3C0 | 4 (best 0.83) |
| 5ZK8 | Crystal structure of M2 muscarinic acetylcholine receptor bound with nms | x-ray diffraction | A | 3C0 | — |
| 5ZKB | Crystal structure of rationally thermostabilized M2 muscarinic acetylcholine receptor bound with… | x-ray diffraction | A | 82F | 6 (best 0.78) |
| 5ZKB | Crystal structure of rationally thermostabilized M2 muscarinic acetylcholine receptor bound with… | x-ray diffraction | A | 82F | — |
| 5ZKC | Crystal structure of rationally thermostabilized M2 muscarinic acetylcholine receptor bound with NMS | x-ray diffraction | A | 3C0 | — |
| 5ZKC | Crystal structure of rationally thermostabilized M2 muscarinic acetylcholine receptor bound with nms | x-ray diffraction | A | 3C0 | — |
| 6OIK | Muscarinic acetylcholine receptor 2-Go complex | electron microscopy | R | IXO, 2CU | 3 (best 0.74) |
| 6OIK | Muscarinic acetylcholine receptor 2-go complex | electron microscopy | R | IXO, 2CU | — |
| 6U1N | GPCR-Beta arrestin structure in lipid bilayer | electron microscopy | R | 2CU | 3 (best 0.82) |
| 6U1N | GPCR-beta arrestin structure in lipid bilayer | electron microscopy | R | 2CU | — |
| 7T8X | Cryo-EM structure of ACh-bound M2R-Go signaling complex in S1 state | electron microscopy | A | ACH | 6 (best 0.79) |
| 7T90 | Cryo-EM structure of ACh-bound M2R-Go signaling complex in S2 state | electron microscopy | A | ACH | — |
| 7T94 | Cryo-EM structure of S1 state ACh-bound M2R-Go signaling complex with a PAM | electron microscopy | A | ACH, 2CU | — |
| 7T96 | Cryo-EM structure of S2 state ACh-bound M2R-Go signaling complex with a PAM | electron microscopy | A | ACH, 2CU | 4 (best 0.76) |
| 8J8R | Structure of beta-arrestin2 in complex with M2Rpp | electron microscopy | G, U, V | — | 5 (best 0.76) |
| 8J97 | Structure of Muscarinic receptor (M2R) in complex with beta-arrestin1 (Local refine, cross-linked) | electron microscopy | V | — | 1 (best 0.66) |
| 8JAF | Structure of Muscarinic receptor (M2R) in complex with beta-arrestin1 (Local Refine, non-cross… | electron microscopy | V | — | 1 (best 0.73) |
| P08172 | AlphaFold monomer V2.0 prediction for muscarinic acetylcholine receptor M2 (P08172) | predicted | A | — | — |
Ligands
- 2CU · 3-amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methylpiperazin-1-yl)-2-oxoethoxy]thieno[2,3-b]pyridine-2-carboxamide · in 6 records
- 3C0 · N-methyl scopolamine · in 6 records
- ACH · Acetylcholine · in 4 records
- 82F · N-[2-[(2S)-2-[(dipropylamino)methyl]piperidin-1-yl]ethyl]-6-oxidanylidene-5H-pyrido[2,3-B][1, 4]benzodiazepine-11-carboxamide · in 2 records
- HG · Mercury (II) ion · in 2 records
- IXO · 4-(4,5-dihydro-1,2-oxazol-3-yloxy)-N,N,N-trimethylbut-2-yn-1-aminium · in 2 records
- QNB · (3R)-1-azabicyclo[2.2.2]oct-3-yl hydroxy(diphenyl) acetate · in 2 records
Experiment against prediction
- 4MQT chain A against the predicted model P08172: TM-score 0.93, RMSD 2.01 Å
- 4MQT chain A against the predicted model P08172: TM-score 0.93, RMSD 2.01 Å
- 7T8X chain A against the predicted model P08172: TM-score 0.93, RMSD 1.86 Å
- 4MQS chain A against the predicted model P08172: TM-score 0.92, RMSD 2.22 Å
- 4MQS chain A against the predicted model P08172: TM-score 0.92, RMSD 2.22 Å
- 6OIK chain R against the predicted model P08172: TM-score 0.92, RMSD 2.09 Å
- 6OIK chain R against the predicted model P08172: TM-score 0.92, RMSD 2.09 Å
- 7T94 chain A against the predicted model P08172: TM-score 0.92, RMSD 2.07 Å
- 7T96 chain A against the predicted model P08172: TM-score 0.91, RMSD 2.11 Å
- 7T90 chain A against the predicted model P08172: TM-score 0.91, RMSD 2.20 Å
Elsewhere
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