GPCR-beta arrestin structure in lipid bilayer

Structure

electron microscopy · 4 distinct chains.

Ligands and binding sites

• 2CU · 3-amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methylpiperazin-1-yl)-2-oxoethoxy]thieno[2,3-b]pyridine-2-carboxamide · ligand · chains R

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 6U1N · GPCR-Beta arrestin structure in lipid bilayer · the same entry in another collection · chain R against R, TM-score 1.00
• P29066 · AlphaFold monomer V2.0 prediction for beta-arrestin-1 (P29066) · a predicted model of the same protein · chain C against A, TM-score 0.89
• P08172 · AlphaFold monomer V2.0 prediction for muscarinic acetylcholine receptor M2 (P08172) · a predicted model of the same protein · chain R against A, TM-score 0.86
• P30518 · AlphaFold monomer V2.0 prediction for vasopressin V2 receptor (P30518) · a predicted model of the same protein · chain R against A, TM-score 0.78

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P08172
• Every structure of UniProt P30518
• Every structure of UniProt P29066
• Every structure of UniProt V9HW68
• Every structure of UniProt Q7Z3Y4
• Elsewhere: RCSB PDB 6U1N · PDBe 6U1N · UniProt P08172 · UniProt P30518 · UniProt P29066 · UniProt V9HW68 · UniProt Q7Z3Y4