UniProt P30518
Vasopressin V2 receptor (P30518)
Vasopressin V2 receptor (UniProt P30518): 22 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 72 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P30518
- Protein
- Vasopressin V2 receptor
- Experimental structures
- 22
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 72 · 15 records with a druggable one
Structures
23 records of P30518 in the MolNFT archive: 22 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4JQI | Structure of active beta-arrestin1 bound to a G protein-coupled receptor phosphopeptide | x-ray diffraction | V | — | — |
| 4JQI | Structure of active beta-ARRESTIN1 bound to a G protein-coupled receptor phosphopeptide | x-ray diffraction | V | — | — |
| 6NI2 | Stabilized beta-arrestin 1-V2T subcomplex of a GPCR-G protein-beta-arrestin mega-complex | electron microscopy | V | — | 2 (best 0.80) |
| 6NI2 | Stabilized beta-arrestin 1-V2T subcomplex of a GPCR-G protein-beta- arrestin mega-complex | electron microscopy | V | — | — |
| 6U1N | GPCR-Beta arrestin structure in lipid bilayer | electron microscopy | R | 2CU | 3 (best 0.82) |
| 6U1N | GPCR-beta arrestin structure in lipid bilayer | electron microscopy | R | 2CU | — |
| 7BB6 | AVP-V2R-Galphas-beta1-gamma2-Nb35 (L state) | electron microscopy | A | — | 5 (best 0.83) |
| 7BB6 | Avp-V2R-galphas-BETA1-GAMMA2-NB35 (L state) | electron microscopy | A | — | — |
| 7BB7 | AVP-V2R-Galphas-beta1-gamma2-Nb35(T state) | electron microscopy | A | — | 8 (best 0.81) |
| 7BB7 | Avp-V2R-galphas-BETA1-GAMMA2-NB35(T state) | electron microscopy | A | — | — |
| 7DW9 | Cryo-EM structure of human V2 vasopressin receptor in complex with an Gs protein | electron microscopy | R | CLR | 1 (best 0.72) |
| 7DW9 | Cryo-EM structure of human V2 vasopressin receptor in complex with an gs protein | electron microscopy | R | NH2, CLR | — |
| 7KH0 | Cryo-EM structure of the human arginine vasopressin AVP-vasopressin receptor V2R-Gs signaling… | electron microscopy | R | — | 4 (best 0.72) |
| 7KH0 | Cryo-EM structure of the human arginine vasopressin avp-vasopressin receptor V2R-gs signaling… | electron microscopy | R | — | — |
| 7R0C | Structure of the AVP-V2R-arrestin2-ScFv30 complex | electron microscopy | A | — | 12 (best 0.82) |
| 8GOC | Structure of beta-arrestin2 in complex with a phosphopeptide corresponding to the human Vasopressin… | electron microscopy | G, U, V | — | 5 (best 0.70) |
| 8I10 | Structure of beta-arrestin2 in complex with a phosphopeptide corresponding to the human Vasopressin… | electron microscopy | G, U, V | — | 6 (best 0.69) |
| 8JRU | Cryo-EM structure of the glucagon receptor bound to beta-arrestin 1 in ligand-free state | electron microscopy | R | PIO | 5 (best 0.75) |
| 8JRV | Cryo-EM structure of the glucagon receptor bound to glucagon and beta-arrestin 1 | electron microscopy | R | PIO | 6 (best 0.78) |
| 8WRZ | Cry-EM structure of cannabinoid receptor-beta-arrestin-1 complex | electron microscopy | V | — | 2 (best 0.71) |
| 9BT8 | Structure of Src in complex with beta-arrestin 1 revealing SH3 binding sites | electron microscopy | V | — | 5 (best 0.69) |
| 9CX3 | Structure of SH3 domain of Src in complex with beta-arrestin 1 | electron microscopy | V | — | 5 (best 0.73) |
| P30518 | AlphaFold monomer V2.0 prediction for vasopressin V2 receptor (P30518) | predicted | A | — | 3 (best 0.72) |
Ligands
- 2CU · 3-amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methylpiperazin-1-yl)-2-oxoethoxy]thieno[2,3-b]pyridine-2-carboxamide · in 2 records
- CLR · Cholesterol · in 2 records
- PIO · [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2, 3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate · in 2 records
- NH2 · Amino group · in 1 record
Experiment against prediction
- 7KH0 chain R against the predicted model P30518: TM-score 0.90, RMSD 2.37 Å
- 7KH0 chain R against the predicted model P30518: TM-score 0.90, RMSD 2.37 Å
- 7DW9 chain R against the predicted model P30518: TM-score 0.89, RMSD 2.43 Å
- 7DW9 chain R against the predicted model P30518: TM-score 0.89, RMSD 2.43 Å
- 7R0C chain A against the predicted model P30518: TM-score 0.86, RMSD 3.01 Å
- 6U1N chain R against the predicted model P08172: TM-score 0.86, RMSD 2.33 Å
- 6U1N chain R against the predicted model P08172: TM-score 0.86, RMSD 2.33 Å
- 8JRU chain R against the predicted model P47871: TM-score 0.82, RMSD 2.93 Å
- 8JRV chain R against the predicted model P47871: TM-score 0.81, RMSD 3.42 Å
- 7BB6 chain A against the predicted model P30518: TM-score 0.81, RMSD 3.34 Å
Elsewhere
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