Cryo-EM structure of PW0464 bound dopamine receptor DRD1-gs signaling complex

Structure

electron microscopy · 5 distinct chains.

Ligands and binding sites

• CLR · Cholesterol · ligand · chains R
• G3U · 6-[4-[3-[bis(fluoranyl)methoxy]pyridin-2-yl]oxy-2-methyl-phenyl]-1,5-dimethyl-pyrimidine-2,4-dione · ligand · chains R

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 7CKY · Cryo-EM structure of PW0464 bound dopamine receptor DRD1-Gs signaling complex · the same entry in another collection · chain R against R, TM-score 1.00
• P62873 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain B against A, TM-score 0.98
• P21728 · AlphaFold monomer V2.0 prediction for D(1A) dopamine receptor (P21728) · a predicted model of the same protein · chain R against A, TM-score 0.89
• P59768 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(O)… · a predicted model of the same protein · chain G against A, TM-score 0.82

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P63092
• Every structure of UniProt P62873
• Every structure of UniProt P59768
• Every structure of UniProt P21728
• Elsewhere: RCSB PDB 7CKY · PDBe 7CKY · UniProt P63092 · UniProt P62873 · UniProt P59768 · UniProt P21728