Research workbench
CRF1 receptor gs GPCR protein complex with CRF1 peptide
Analyse CRF1 receptor gs GPCR protein complex with CRF1 peptide in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6P9X
- Type
- protein
- Length
- 1,015 residues
- Chains
- 6
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Guanine nucleotide-binding protein G(S) subunit alpha isoforms short; Guanine…
- UniProt
- P63092, P62873, P59768, P34998, P06850
- Pockets
- 13 · best druggability 0.84
Structure
electron microscopy · 6 distinct chains · 37% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Guanine nucleotide-binding protein G(S) subunit alpha isoforms short | protein | 192 | 42% helix, 18% strand | P63092 |
| B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | protein | 338 | 7% helix, 49% strand | P62873 |
| G | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | protein | 56 | 46% helix, 0% strand | P59768 |
| N | Nanobody 35 | protein | 126 | 5% helix, 42% strand | — |
| R | Corticotropin-releasing factor receptor 1 | protein | 270 | 79% helix, 0% strand | P34998 |
| P | Corticoliberin | protein | 33 | 76% helix, 3% strand | P06850 |
Pockets
13 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 855 | 0.84 | 0.87 | 79 | empty |
| 2 | 850 | 0.75 | 0.79 | 62 | empty |
| 3 | 1009 | 0.75 | 0.78 | 66 | empty |
| 4 | 89 | 0.63 | 0.90 | 22 | empty |
| 5 | 259 | 0.59 | 0.79 | 36 | empty |
Interfaces
8 interfaces between chains.
- B–G · 2194 Ų buried · 22 hydrogen bonds · protein-protein
- A–B · 1492 Ų buried · 21 hydrogen bonds · protein-protein
- R–P · 1382 Ų buried · 6 hydrogen bonds · protein-protein
- A–R · 1084 Ų buried · 13 hydrogen bonds · protein-protein
- A–N · 849 Ų buried · 8 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 3 disulfide (disulfide).
Compared structures
- 6P9X · CRF1 Receptor Gs GPCR protein complex with CRF1 peptide · the same entry in another collection · chain P against P, TM-score 1.00
- P62873 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain B against A, TM-score 1.00
- P34998 · AlphaFold monomer V2.0 prediction for corticotropin-releasing factor receptor 1 (P34998) · a predicted model of the same protein · chain R against A, TM-score 0.96
- P59768 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(O)… · a predicted model of the same protein · chain G against A, TM-score 0.92
- P63092 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(S) subunit… · a predicted model of the same protein · chain A against A, TM-score 0.82
- P06850 · AlphaFold monomer V2.0 prediction for corticoliberin (P06850) · a predicted model of the same protein · chain P against A, TM-score 0.71
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P63092
- Every structure of UniProt P62873
- Every structure of UniProt P59768
- Every structure of UniProt P34998
- Every structure of UniProt P06850
- Elsewhere: RCSB PDB 6P9X · PDBe 6P9X · UniProt P63092 · UniProt P62873 · UniProt P59768 · UniProt P34998 · UniProt P06850
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