Triazolopyrimidines stabilize microtubules by binding to the vinca inhibitor site of tubulin

Structure

x-ray diffraction · 6 distinct chains.

Ligands and binding sites

• GTP · Guanosine-5'-triphosphate · ligand · 2 copies · chains A, B, C, D
• GDP · Guanosine-5'-diphosphate · ligand · 2 copies · chains B, D
• 8Z8 · 5-chloranyl-7-[(1~{R},5~{S})-3-methoxy-8-azabicyclo[3.2.1]octan-8-yl]-6-[2,4,6-tris(fluoranyl) phenyl]-[1,2,4]triazolo[1,5-a]pyrimidine · ligand · chains B, C
• ACP · Phosphomethylphosphonic acid adenylate ester · ligand · chains F
• MG · Magnesium ion · metal · 5 copies · chains B, D, F

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 5NJH · Triazolopyrimidines stabilize microtubules by binding to the vinca inhibitor site of… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P81947
• Every structure of UniProt Q6B856
• Every structure of UniProt P63043
• Every structure of UniProt E1BQ43
• Elsewhere: RCSB PDB 5NJH · PDBe 5NJH · UniProt P81947 · UniProt Q6B856 · UniProt P63043 · UniProt E1BQ43