Research workbench
AlphaFold monomer V2.0 prediction for telomerase reverse transcriptase (O14746)
Analyse AlphaFold monomer V2.0 prediction for telomerase reverse transcriptase (O14746) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- Accession
- O14746
- Type
- protein
- Length
- 1,132 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x6b39F1Efd15E3EA6E24CA4E8bE61efce2D0fAfD8
- Molecule
- Telomerase reverse transcriptase
- UniProt
- O14746
- Pockets
- 15 · best druggability 0.58
Structure
1 distinct chain · 41% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Telomerase reverse transcriptase | protein | 1132 | 41% helix, 13% strand | O14746 |
Pockets
15 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 205 | 0.58 | 0.80 | 27 | empty |
| 2 | 134 | 0.54 | 0.81 | 17 | empty |
| 3 | 266 | 0.52 | 0.75 | 29 | empty |
| 4 | 199 | 0.51 | 0.77 | 24 | empty |
| 5 | 239 | 0.49 | 0.74 | 38 | empty |
Compared structures
- 7V99 · Catalytic core of human telomerase holoenzyme · an experimental structure of the same protein · chain A against A, TM-score 0.79
- 7V99 · catalytic core of human telomerase holoenzyme · an experimental structure of the same protein · chain A against A, TM-score 0.79
- 7TRE · Human telomerase catalytic core with shelterin protein TPP1 · an experimental structure of the same protein · chain A against A, TM-score 0.78
- 7TRE · Human telomerase catalytic core with shelterin protein TPP1 · an experimental structure of the same protein · chain A against A, TM-score 0.78
- 7TRD · Human telomerase catalytic core structure at 3.3 ångström · an experimental structure of the same protein · chain A against A, TM-score 0.78
- 7TRD · Human telomerase catalytic core structure at 3.3 Angstrom · an experimental structure of the same protein · chain A against A, TM-score 0.78
- 7TRF · Human telomerase catalytic core RNP with H2A/H2B · an experimental structure of the same protein · chain A against A, TM-score 0.78
- 7TRF · Human telomerase catalytic core rnp with H2A/H2B · an experimental structure of the same protein · chain A against A, TM-score 0.78
- 7QXA · Cryo-EM map of human telomerase-DNA-TPP1 complex (sharpened) · an experimental structure of the same protein · chain A against A, TM-score 0.78
- 7QXA · Cryo-EM MAP of human telomerase-DNA-TPP1 complex (sharpened) · an experimental structure of the same protein · chain A against A, TM-score 0.78
- 7QXB · Cryo-EM MAP of human telomerase-DNA-TPP1-POT1 complex (sharpened MAP) · an experimental structure of the same protein · chain A against A, TM-score 0.77
- 7QXB · Cryo-EM map of human telomerase-DNA-TPP1-POT1 complex (sharpened map) · an experimental structure of the same protein · chain A against A, TM-score 0.77
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O14746
- Elsewhere: UniProt O14746 · AlphaFold DB O14746
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