MolNFT v1 · #188426 · protein + DNA + RNA
Human telomerase catalytic core structure at 3.3 ångström
7TRD · Telomerase RNA, partial sequence: “Human telomerase catalytic core structure at 3.3 ångström”. Electron microscopy, 20 pockets (best druggability 0.86). MolNFT v1 #188426 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7TRD
- Type
- protein + DNA + RNA
- Length
- 1,158 residues
- Chains
- 3
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Telomerase RNA, partial sequence; Telomerase reverse transcriptase; Telomeric repeat…
- EC
- 2.7.7.49
- UniProt
- O14746
- Pockets
- 20 · best druggability 0.86
Structure
electron microscopy · 3 distinct chains · 47% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | Telomerase RNA, partial sequence | rna | 217 | — | — |
| A | Telomerase reverse transcriptase (EC 2.7.7.49) | protein | 934 | 47% helix, 16% strand | O14746 |
| N | Telomeric repeat substrate | dna | 7 | — | — |
Pockets
20 pockets found on a 1 Å grid, 14 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1139 | 0.86 | 0.87 | 95 | empty |
| 2 | 1175 | 0.80 | 0.82 | 71 | empty |
| 3 | 1053 | 0.78 | 0.80 | 53 | empty |
| 4 | 1071 | 0.74 | 0.77 | 62 | empty |
| 5 | 407 | 0.68 | 0.80 | 47 | empty |
Interfaces
3 interfaces between chains.
- B–A · 6138 Ų buried · 102 hydrogen bonds · protein-nucleic
- A–N · 755 Ų buried · 10 hydrogen bonds · protein-nucleic
- B–N · 337 Ų buried · 13 hydrogen bonds · nucleic-nucleic
Compared structures
- 7TRD · Human telomerase catalytic core structure at 3.3 Angstrom · the same entry in another collection · chain B against B, TM-score 1.00
- O14746 · AlphaFold monomer V2.0 prediction for telomerase reverse transcriptase (O14746) · a predicted model of the same protein · chain A against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O14746
- Elsewhere: RCSB PDB 7TRD · PDBe 7TRD · UniProt O14746
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