UniProt O14746
Telomerase reverse transcriptase (O14746)
Telomerase reverse transcriptase (UniProt O14746), EC 2.7.7.49: 19 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 54 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- O14746
- Protein
- Telomerase reverse transcriptase
- EC
- 2.7.7.49
- Experimental structures
- 19
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 54 · 3 records with a druggable one
Structures
20 records of O14746 in the MolNFT archive: 19 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2BCK | Crystal Structure of HLA-A*2402 Complexed with a telomerase peptide | x-ray diffraction | C, F | — | — |
| 2BCK | Crystal structure of HLA-A*2402 complexed with a telomerase peptide | x-ray diffraction | C, F | — | — |
| 4B18 | The crystal structure of human Importin alpha 5 with TERT NLS peptide | x-ray diffraction | B | — | — |
| 4B18 | The crystal structure of human importin alpha 5 with tert nls peptide | x-ray diffraction | B | — | — |
| 4MNQ | TCR-peptide specificity overrides affinity enhancing TCR-MHC interactions | x-ray diffraction | C | — | — |
| 4MNQ | TCR-peptide specificity overrides affinity enhancing TCR-MHC interactions | x-ray diffraction | C | — | — |
| 5UGW | Structure of the human telomerase thumb domain | x-ray diffraction | A | GSH | 2 (best 0.32) |
| 5UGW | Structure of the human telomerase thumb domain | x-ray diffraction | A | GSH | — |
| 7BG9 | The catalytic core lobe of human telomerase in complex with a telomeric DNA substrate | electron microscopy | A | — | 18 (best 0.83) |
| 7BG9 | The catalytic core lobe of human telomerase in complex with a telomeric DNA substrate | electron microscopy | A | — | — |
| 7QXA | Cryo-EM MAP of human telomerase-DNA-TPP1 complex (sharpened) | electron microscopy | A | — | — |
| 7QXB | Cryo-EM MAP of human telomerase-DNA-TPP1-POT1 complex (sharpened MAP) | electron microscopy | A | — | — |
| 7QXS | Cryo-EM structure of human telomerase-DNA-TPP1-POT1 complex (with POT1 side chains) | electron microscopy | A | — | — |
| 7TRD | Human telomerase catalytic core structure at 3.3 Angstrom | electron microscopy | A | — | — |
| 7TRD | Human telomerase catalytic core structure at 3.3 ångström | electron microscopy | A | — | — |
| 7TRE | Human telomerase catalytic core with shelterin protein TPP1 | electron microscopy | A | — | — |
| 7TRF | Human telomerase catalytic core rnp with H2A/H2B | electron microscopy | A | — | — |
| 7V99 | catalytic core of human telomerase holoenzyme | electron microscopy | A | — | 19 (best 0.84) |
| 7V99 | Catalytic core of human telomerase holoenzyme | electron microscopy | A | — | — |
| O14746 | AlphaFold monomer V2.0 prediction for telomerase reverse transcriptase (O14746) | predicted | A | — | 15 (best 0.58) |
Ligands
- GSH · Glutathione · in 2 records
Experiment against prediction
- 7TRE chain A against the predicted model O14746: TM-score 0.94, RMSD 2.60 Å
- 7TRD chain A against the predicted model O14746: TM-score 0.94, RMSD 2.61 Å
- 7TRD chain A against the predicted model O14746: TM-score 0.94, RMSD 2.61 Å
- 7TRF chain A against the predicted model O14746: TM-score 0.94, RMSD 2.61 Å
- 7QXA chain A against the predicted model O14746: TM-score 0.92, RMSD 3.23 Å
- 7BG9 chain A against the predicted model O14746: TM-score 0.91, RMSD 3.16 Å
- 7BG9 chain A against the predicted model O14746: TM-score 0.91, RMSD 3.16 Å
- 7QXB chain A against the predicted model O14746: TM-score 0.91, RMSD 3.53 Å
- 7QXS chain A against the predicted model O14746: TM-score 0.91, RMSD 3.53 Å
- 7V99 chain A against the predicted model O14746: TM-score 0.89, RMSD 3.68 Å
Elsewhere
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