MolNFT v1 · #188427 · protein + DNA + RNA
Human telomerase catalytic core with shelterin protein TPP1
7TRE · Telomerase RNA, partial sequence: “Human telomerase catalytic core with shelterin protein TPP1”. Electron microscopy, 20 pockets (best druggability 0.80). MolNFT v1 #188427 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 7TRE
- Type
- protein + DNA + RNA
- Length
- 1,310 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Telomerase RNA, partial sequence; Telomerase reverse transcriptase; Telomeric repeat…
- EC
- 2.7.7.49
- UniProt
- O14746, Q96AP0
- Pockets
- 20 · best druggability 0.80
Structure
electron microscopy · 4 distinct chains · 43% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | Telomerase RNA, partial sequence | rna | 217 | — | — |
| A | Telomerase reverse transcriptase (EC 2.7.7.49) | protein | 934 | 47% helix, 16% strand | O14746 |
| D | Telomeric repeat substrate | dna | 7 | — | — |
| C | Adrenocortical dysplasia protein homolog | protein | 152 | 19% helix, 27% strand | Q96AP0 |
Pockets
20 pockets found on a 1 Å grid, 13 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1079 | 0.80 | 0.82 | 93 | empty |
| 2 | 1101 | 0.80 | 0.82 | 89 | empty |
| 3 | 1095 | 0.77 | 0.80 | 57 | empty |
| 4 | 865 | 0.76 | 0.81 | 51 | empty |
| 5 | 865 | 0.76 | 0.80 | 76 | empty |
Interfaces
4 interfaces between chains.
- B–A · 6143 Ų buried · 95 hydrogen bonds · protein-nucleic
- A–C · 990 Ų buried · 4 hydrogen bonds · protein-protein
- A–D · 777 Ų buried · 7 hydrogen bonds · protein-nucleic
- B–D · 329 Ų buried · 14 hydrogen bonds · nucleic-nucleic
Compared structures
- 7TRE · Human telomerase catalytic core with shelterin protein TPP1 · the same entry in another collection · chain B against B, TM-score 1.00
- O14746 · AlphaFold monomer V2.0 prediction for telomerase reverse transcriptase (O14746) · a predicted model of the same protein · chain A against A, TM-score 0.94
- Q96AP0 · AlphaFold monomer V2.0 prediction for adrenocortical dysplasia protein homolog (Q96AP0) · a predicted model of the same protein · chain C against A, TM-score 0.89
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O14746
- Every structure of UniProt Q96AP0
- Elsewhere: RCSB PDB 7TRE · PDBe 7TRE · UniProt O14746 · UniProt Q96AP0
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