UniProt Q96AP0
Adrenocortical dysplasia protein homolog (Q96AP0)
Adrenocortical dysplasia protein homolog (UniProt Q96AP0), EC 2.7.7.48, 3.4.22.28: 13 experimental structures and 1 predicted model on GenesisL1, 6 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- Q96AP0
- Protein
- Adrenocortical dysplasia protein homolog
- EC
- 2.7.7.48, 3.4.22.28, 3.4.22.29, 3.6.1.15
- Experimental structures
- 13
- Predicted models
- 1
- Pockets
- 6 · 3 records with a druggable one
Structures
14 records of Q96AP0 in the MolNFT archive: 13 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2I46 | Crystal structure of human TPP1 | x-ray diffraction | A, B | — | — |
| 2I46 | Crystal structure of human TPP1 | x-ray diffraction | A, B | — | — |
| 5H65 | Crystal structure of human POT1 and TPP1 | x-ray diffraction | B | — | 2 (best 0.67) |
| 5H65 | Crystal structure of human POT1 and TPP1 | x-ray diffraction | B | — | — |
| 5I2X | Crystal structure of TPP1 K170DEL | x-ray diffraction | A, B | — | — |
| 5I2Y | Crystal Structure of TPP1 K170A | x-ray diffraction | A, B | — | 2 (best 0.56) |
| 5I2Y | Crystal structure of TPP1 K170A | x-ray diffraction | A, B | — | — |
| 5UN7 | Structure of the human POT1-TPP1 telomeric complex | x-ray diffraction | B | — | — |
| 5UN7 | Structure of the human POT1-TPP1 telomeric complex | x-ray diffraction | B | — | — |
| 5XYF | Crystal structure of the human TIN2-TPP1-TRF2 telomeric complex | x-ray diffraction | B | — | — |
| 7S1T | Structure of the human POT1-TPP1 complex | x-ray diffraction | B, E, H, K | — | — |
| 7TRE | Human telomerase catalytic core with shelterin protein TPP1 | electron microscopy | C | — | — |
| 8SOK | Cryo-EM structure of human CST bound to POT1(ESDL)/TPP1 in the presence of telomeric ssDNA | electron microscopy | E | — | 2 (best 0.68) |
| Q96AP0 | AlphaFold monomer V2.0 prediction for adrenocortical dysplasia protein homolog (Q96AP0) | predicted | A | — | — |
Experiment against prediction
- 5I2X chain A against the predicted model Q96AP0: TM-score 0.98, RMSD 0.68 Å
- 2I46 chain A against the predicted model Q96AP0: TM-score 0.98, RMSD 0.77 Å
- 2I46 chain A against the predicted model Q96AP0: TM-score 0.98, RMSD 0.77 Å
- 5I2Y chain A against the predicted model Q96AP0: TM-score 0.98, RMSD 0.76 Å
- 5I2Y chain A against the predicted model Q96AP0: TM-score 0.98, RMSD 0.76 Å
- 2I46 chain B against the predicted model Q96AP0: TM-score 0.96, RMSD 0.97 Å
- 2I46 chain B against the predicted model Q96AP0: TM-score 0.96, RMSD 0.97 Å
- 5I2Y chain B against the predicted model Q96AP0: TM-score 0.96, RMSD 1.03 Å
- 5I2Y chain B against the predicted model Q96AP0: TM-score 0.96, RMSD 1.03 Å
- 5I2X chain B against the predicted model Q96AP0: TM-score 0.96, RMSD 1.07 Å
Elsewhere
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