UniProt Q9WVG6

Histone-arginine methyltransferase CARM1 (Q9WVG6)

Histone-arginine methyltransferase CARM1 (UniProt Q9WVG6), EC 2.1.1.319: 60 experimental structures and 1 predicted model on GenesisL1, 34 ligands bound, 170 pockets. Binding sites, druggability and experiment against prediction…

UniProt: Q9WVG6
Protein: Histone-arginine methyltransferase CARM1
EC: 2.1.1.319
Experimental structures: 60
Predicted models: 1
Ligands: 34
Pockets: 170 · 16 records with a druggable one

Structures

61 records of Q9WVG6 in the MolNFT archive: 60 experimental, 1 predicted.

Entry	Title	Method	Chains	Ligands	Pockets
2V74	Crystal structure of coactivator-associated arginine methyltransferase 1 (CARM1), in complex with…	x-ray diffraction	B, D, F, H	—	—
2V74	Crystal structure of coactivator-associated arginine methyltransferase 1 (CARM1), in complex with…	x-ray diffraction	B, D, F, H	—	—
2V7E	Crystal structure of coactivator-associated arginine methyltransferase 1 (CARM1), unliganded	x-ray diffraction	A, B	—	—
2V7E	Crystal structure of coactivator-associated arginine methyltransferase 1 (CARM1), unliganded	x-ray diffraction	A, B	—	—
5IH3	Crystal structure of mouse CARM1 in complex with SAH at 1.8 Angstroms resolution	x-ray diffraction	A, B, C, D	DXE	—
5IH3	Crystal structure of mouse CARM1 in complex with sah at 1.8 ångströms resolution	x-ray diffraction	A, B, C, D	—	—
5IS6	Crystal structure of mouse CARM1 in complex with Sinefungin at 2.0 Angstroms resolution	x-ray diffraction	A, B, C, D	DXE, SFG	9 (best 0.83)
5IS6	Crystal structure of mouse CARM1 in complex with sinefungin at 2.0 ångströms resolution	x-ray diffraction	A, B, C, D	—	—
5IS7	Crystal structure of mouse CARM1 in complex with decarboxylated SAH	x-ray diffraction	A, B, C, D	DSH	5 (best 0.83)
5IS7	Crystal structure of mouse CARM1 in complex with decarboxylated sah	x-ray diffraction	A, B, C, D	—	—
5IS8	Crystal structure of mouse CARM1 in complex with inhibitor SA0271	x-ray diffraction	A, B, D, C	6D1, SAH	12 (best 0.84)
5IS8	Crystal structure of mouse CARM1 in complex with inhibitor SA0271	x-ray diffraction	A, B, D, C	—	—
5IS9	Crystal structure of mouse CARM1 in complex with inhibitor SA0375	x-ray diffraction	A, B, C, D	6D3, DXE, M2M	8 (best 0.83)
5IS9	Crystal structure of mouse CARM1 in complex with inhibitor SA0375	x-ray diffraction	A, B, C, D	—	—
5ISA	Crystal structure of mouse CARM1 in complex with inhibitor SA0401	x-ray diffraction	C, D, A, B	—	—
5ISB	Crystal structure of mouse CARM1 in complex with inhibitor SA0435	x-ray diffraction	A, B, C, D	—	—
5ISC	Crystal structure of mouse CARM1 in complex with inhibitor SA0491	x-ray diffraction	A, B, C, D	SAO, 6D0, DXE, M2M	10 (best 0.87)
5ISC	Crystal structure of mouse CARM1 in complex with inhibitor SA0491	x-ray diffraction	A, B, C, D	—	—
5ISD	Crystal structure of mouse CARM1 in complex with inhibitor SA0592	x-ray diffraction	A, B, C, D	M2M, 6CZ	—
5ISD	Crystal structure of mouse CARM1 in complex with inhibitor SA0592	x-ray diffraction	A, B, C, D	—	—
5ISE	Crystal structure of mouse CARM1 in complex with inhibitor SA0649	x-ray diffraction	A, B, C, D	—	—
5ISF	Crystal structure of mouse CARM1 in complex with inhibitor SA0705	x-ray diffraction	A, B, C, D	6D4, M2M, DXE, SAO	6 (best 0.85)
5ISF	Crystal structure of mouse CARM1 in complex with inhibitor SA0705	x-ray diffraction	A, B, C, D	—	—
5ISG	Crystal structure of mouse CARM1 in complex with inhibitor SA0707	x-ray diffraction	A, B, C, D	DXE, 6D6, M2M	11 (best 0.84)
5ISG	Crystal structure of mouse CARM1 in complex with inhibitor SA0707	x-ray diffraction	A, B, C, D	—	—
5ISH	Crystal structure of mouse CARM1 in complex with inhibitor SA0765	x-ray diffraction	A, B, C, D	765, DXE, M2M	9 (best 0.84)
5ISH	Crystal structure of mouse CARM1 in complex with inhibitor SA0765	x-ray diffraction	A, B, C, D	—	—
5ISI	Crystal structure of mouse CARM1 in complex with inhibitor SA0920 (5'- amino-5'-deoxyadenosine)	x-ray diffraction	A, B, C, D	—	—
5K8V	Crystal Structure of Mus musculus Protein Arginine Methyltransferase 4 (CARM1 130-487) with CP1	x-ray diffraction	A, B, C, D	6RE, DXE	9 (best 0.83)
5K8V	Crystal structure of mus musculus protein arginine methyltransferase 4 (CARM1 130-487) with CP1	x-ray diffraction	A, B, C, D	6RE, DXE	—
5K8W	Crystal structure of mouse CARM1 in complex with inhibitor U2	x-ray diffraction	A, B, C, D	GJV, DXE	—
5K8X	Crystal structure of mouse CARM1 in complex with inhibitor U3	x-ray diffraction	A, B, C, D	6ZH, DXE, M2M	—
5LGP	Crystal structure of mouse CARM1 in complex with ligand P1C3s	x-ray diffraction	A, B, C, D	8ZB	—
5LGP	Crystal structure of mouse CARM1 in complex with ligand P1C3S	x-ray diffraction	A, B, C, D	8ZB	—
5LGQ	Crystal structure of mouse CARM1 in complex with ligand P2C3s	x-ray diffraction	A, B, C, D	DXE, SO4, 8ZB	11 (best 0.81)
5LGQ	Crystal structure of mouse CARM1 in complex with ligand P2C3S	x-ray diffraction	A, B, C, D	DXE, SO4, 8ZB	—
5LGR	Crystal structure of mouse CARM1 in complex with ligand P1C3u	x-ray diffraction	A, B, C, D	SO4, DXE, QVR, LPD	14 (best 0.82)
5LGR	Crystal structure of mouse CARM1 in complex with ligand P1C3U	x-ray diffraction	A, B, C, D	SO4, DXE, QVR	—
5LGS	Crystal structure of mouse CARM1 in complex with ligand P2C3u	x-ray diffraction	A, B, C, D	SO4, DXE, QVR	—
5LGS	Crystal structure of mouse CARM1 in complex with ligand P2C3U	x-ray diffraction	A, B, C, D	SO4, DXE, QVR	—
5LKJ	Crystal structure of mouse CARM1 in complex with ligand SA684	x-ray diffraction	A, B, C, D	DXE	—
5LV2	Crystal structure of mouse CARM1 in complex with inhibitor LH1246	x-ray diffraction	A, B, C, D, E, F, G, H	SAO, LHB, M2M, DXE, NA	20 (best 0.84)
5LV2	Crystal structure of mouse CARM1 in complex with inhibitor LH1246	x-ray diffraction	A, B, C, D, E, F, G, H	LHB, M2M, DXE, NA	—
5LV3	Crystal structure of mouse CARM1 in complex with ligand LH1561BR	x-ray diffraction	A, B, C, D	LHF	—
5NTC	Crystal structure of mouse CARM1 in complex with inhibitor SA0678	x-ray diffraction	A, B, C, D	DXE, M2M, 6L7	12 (best 0.82)
5NTC	Crystal structure of mouse CARM1 in complex with inhibitor SA0678	x-ray diffraction	A, B, C, D	DXE, M2M, 6L7	—
5TBH	Crystal structure of mouse CARM1 in complex with inhibitor LH1236	x-ray diffraction	A, B, C, D	M2M, 78K	—
5TBI	Crystal structure of mouse CARM1 in complex with inhibitor LH1427	x-ray diffraction	A, B, C, D	78V	—
5TBJ	Crystal structure of mouse CARM1 in complex with inhibitor LH1452	x-ray diffraction	A, B, C, D	LHD, DXE	—
7OKP	Crystal structure of mouse CARM1 in complex with histone H3_13-22 K18 acetylated	x-ray diffraction	A, B, C, D	QVR	16 (best 0.80)
7OKP	Crystal structure of mouse CARM1 in complex with histone H3_13-22 K18 acetylated	x-ray diffraction	A, B, C, D	ACE, QVR	—
7OS4	Crystal structure of mouse CARM1 in complex with histone H3_13-31 K18	x-ray diffraction	A, B, C, D	ACE, QVR	—
7PPQ	CARM1 in complex with EML736	x-ray diffraction	A, B, C, D	LSK	—
7PPY	CARM1 in complex with EML709	x-ray diffraction	A, B, C, D	7ZH	—
7PU8	CARM1 in complex with EML980	x-ray diffraction	A, B, C, D	4R7	8 (best 0.84)
7PU8	CARM1 in complex with EML980	x-ray diffraction	A, B, C, D	4R7	—
7PUC	CARM1 in complex with EML981	x-ray diffraction	A, B, C, D	85U	—
7PUQ	CARM1 in complex with EML982	x-ray diffraction	A, B, C, D	867	—
7PV6	CARM1 in complex with EML734	x-ray diffraction	A, B, C, D	LRZ	—
7QPH	Crystal structure of mouse CARM1 in complex with histone H3_22-31 K27 acetylated	x-ray diffraction	A, B, C, D	QVR	10 (best 0.81)

1 record more on the page itself.

Ligands

DXE · 1,2-dimethoxyethane · in 23 records
M2M · 1-methoxy-2-(2-methoxyethoxy)ethane · in 12 records
QVR · (2~{R},3~{R},4~{S},5~{R})-2-(6-aminopurin-9-yl)-5-[(~{E})-prop-1-enyl]oxolane-3,4-diol · in 8 records
SO4 · Sulfate ion · in 6 records
8ZB · (2~{R},3~{R},4~{S},5~{R})-2-(6-aminopurin-9-yl)-5-propyl-oxolane-3,4-diol · in 4 records
SAO · 5'-S-[(3S)-3-azaniumyl-3-carboxypropyl]-5'-thioadenosine · in 3 records
4R7 · methyl 6-[4-[[N-[2-[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]ethyl]carbamimidoyl]amino]butylcarbamoylamino]-4-oxidanyl-naphthalene-2-carboxylate · in 2 records
6L7 · [(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl-(2-azaniumylethyl)-[(3~{S})-3-azaniumyl-4-oxidanyl-4-oxidanylidene-butyl]azanium · in 2 records
6RE · [[2-[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3, 4-bis(oxidanyl)oxolan-2-yl]ethylamino]-azanyl-methylidene]azanium · in 2 records
ACE · Acetyl group · in 2 records
LHB · 5-[[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3, 4-bis(oxidanyl)oxolan-2-yl]methylamino]methyl]-4-azanyl-1-(methoxymethyl)pyrimidin-2-one · in 2 records
NA · Sodium ion · in 2 records
6CZ · 5'-{[(3S)-3-amino-3-carboxypropyl](3-ethoxy-2,3-dioxopropyl)amino}-5'-deoxyadenosine · in 1 record
6D0 · 5'-{[(3S)-3-amino-3-carboxypropyl](3-bromo-2-oxopropyl)amino}-5'-deoxyadenosine · in 1 record
6D1 · 5'-{[(3S)-3-amino-3-carboxypropyl](2-chloroethyl)amino}-5'-deoxyadenosine · in 1 record
6D3 · (2S)-2-amino-4-[(3-{4-[(2S)-2-amino-2-carboxyethyl]-1H-1,2,3-triazol-1-yl}propyl){[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl}amino]butanoic acid (non-preferred name) · in 1 record
6D4 · 5'-{[(3S)-3-amino-3-carboxypropyl][2-(triazan-1-yl)ethyl]amino}-5'-deoxyadenosine · in 1 record
6D6 · 5'-{[(3S)-3-amino-3-carboxypropyl](3-aminopropyl) amino}-5'-deoxyadenosine · in 1 record
6ZH · [[[(~{E})-3-[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]prop-2-enyl]amino]-azanyl-methylidene]azanium · in 1 record
765 · 5'-{1-[(3S)-3-amino-3-carboxypropyl]aziridin-1-ium-1-yl}-5'-deoxyadenosine · in 1 record
78K · (2~{R})-4-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl-[[4-azanyl-1-(methoxymethyl)-2-oxidanylidene-pyrimidin-5-yl]methyl]amino]-2-azanyl-butanoic acid · in 1 record
78V · 4-[2-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methylamino]ethylamino]-1-(methoxymethyl)pyrimidin-2-one · in 1 record
7ZH · Methyl 6-[4-[[~{N}-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl]carbamimidoyl]amino]butylcarbamoylamino]-4-oxidanyl-naphthalene-2-carboxylate · in 1 record
85U · Methyl 6-[4-[[~{N}-[(~{E})-3-[(2~{R},3~{S},4~{R}, 5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]prop-2-enyl]carbamimidoyl]amino]butylcarbamoylamino]-4-oxidanyl-naphthalene-2-carboxylate · in 1 record
867 · Methyl 6-[4-[[~{N}-[3-[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]propyl]carbamimidoyl]amino]butylcarbamoylamino]-4-oxidanyl-naphthalene-2-carboxylate · in 1 record
DSH · 5'-S-(3-aminopropyl)-5'-thioadenosine · in 1 record
GJV · 9-(7-{[amino(iminio)methyl]amino}-5,6,7-trideoxy-beta-D-ribo-heptofuranosyl)-9H-purin-6-amine · in 1 record
LHD · 2-[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]ethyl-[[4-azanyl-1-(methoxymethyl)-2-oxidanylidene-pyrimidin-5-yl]methyl]azanium · in 1 record
LHF · 5-[[2-[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]ethylamino]methyl]-4-azanyl-1-[2-(4-bromanylphenoxy)ethyl]pyrimidin-2-one · in 1 record
LPD · L-prolinamide · in 1 record

Experiment against prediction

5ISG chain A against the predicted model Q9WVG6: TM-score 1.00, RMSD 0.23 Å
5ISG chain A against the predicted model Q9WVG6: TM-score 1.00, RMSD 0.23 Å
5ISA chain A against the predicted model Q9WVG6: TM-score 1.00, RMSD 0.25 Å
5IS6 chain A against the predicted model Q9WVG6: TM-score 1.00, RMSD 0.27 Å
5ISF chain A against the predicted model Q9WVG6: TM-score 1.00, RMSD 0.28 Å
5ISF chain A against the predicted model Q9WVG6: TM-score 1.00, RMSD 0.28 Å
5ISH chain A against the predicted model Q9WVG6: TM-score 1.00, RMSD 0.29 Å
5ISH chain A against the predicted model Q9WVG6: TM-score 1.00, RMSD 0.29 Å
5K8V chain A against the predicted model Q9WVG6: TM-score 1.00, RMSD 0.29 Å
5K8V chain A against the predicted model Q9WVG6: TM-score 1.00, RMSD 0.29 Å

Elsewhere

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