GL1X · GenesisL1 explorer

Ligand · SFG

SFG · Sinefungin

SFG, Sinefungin (C15 H23 N7 O5, 381.4 g/mol), in the MolNFT structures on GenesisL1: bound in 46 records (46 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the ligands found with it.

Component
SFG
Formula
C15 H23 N7 O5
Class
ligand
Structures
46
PDB entries
46

Binding sites

SFG in 46 structures; the first of them:

  • 5DX1 · Crystal structure of CARM1, sinefungin, and PABP1 peptide (R455) · SFG A501 · binds PHE137, TYR149, PHE150, TYR153, GLN159, MET162, ARG168, ASP190 and 17 more
  • 5F8F · Rv2258c-SFG · SFG A401 · binds TYR132, MET142, ALA143, SER146, PHE150, GLY179, CYS180, GLY181 and 11 more
  • 5IS6 · Crystal structure of mouse CARM1 in complex with Sinefungin at 2.0 Angstroms resolution · SFG A507 · binds PHE138, TYR150, PHE151, TYR154, GLN160, MET163, MET164, ARG169 and 17 more
  • 5MRK · Structural basis of Zika virus methyltransferase inhibition by sinefungin · SFG A301 · binds SER56, GLY58, SER59, GLY81, CYS82, GLY83, ARG84, GLY85 and 13 more
  • 5OUF · Crystal structure of OphA-DeltaC6 mutant W400A in complex with Sinefungin · SFG A501 · binds ILE19, TYR98, GLY99, HIS100, VAL103, PHE104, VAL105, VAL128 and 12 more
  • 5TWK · Crystal Structure of RlmH in Complex with Sinefungin · SFG C201 · binds LEU72, ASP73, ILE74, LEU101, ILE102, GLY103, GLY104, PRO105 and 12 more
  • 5W7S · Crystal structure of OxaC in complex with sinefungin and meleagrin · SFG A502 · binds PHE194, TYR198, GLU211, ASP241, ALA243, GLY244, SER245, HIS246 and 12 more
  • 5WWR · Crystal structure of human NSun6/tRNA/SFG · SFG A501 · binds LEU241, CYS242, ALA243, ALA244, PRO245, GLY246, GLY247, LYS248 and 15 more
  • 5WYR · Crystal structure and catalytic mechanism of the essential m1G37 tRNA methyltransferase… · SFG A400 · binds TYR91, LEU92, SER93, PRO94, GLN95, ALA117, GLY118, ARG119 and 20 more
  • 5YNB · Crystal structure of MERS-CoV nsp16/nsp10 complex bound to Sinefungin · SFG A401 · binds ASN43, TYR47, HIS69, GLY71, ALA72, GLY73, SER74, ALA79 and 13 more
  • 6BDY · Crystal Structure of the MetH Reactivation Domain bound to Sinefungin · SFG A1301 · binds ASP946, PRO949, ARG1094, GLU1097, GLU1101, ILE1126, GLU1128, ARG1134 and 8 more
  • 6JKI · Crystal structure and catalytic mechanism of the essential m1G37 tRNA methyltransferase… · SFG A301 · binds TYR91, LEU92, SER93, PRO94, GLN95, ALA117, GLY118, ARG119 and 19 more
  • 6M1C · Crystal structure of RsmD methyltransferase of M. tuberculosis in complex with sinefungin… · SFG A401 · binds ARG22, PRO23, THR24, TYR51, ALA52, GLY53, SER54, GLY55 and 12 more
  • 6V0N · PRMT5 bound to PBM peptide from Riok1 · SFG A701 · binds PRO314, LEU315, LEU319, TYR324, PHE327, LYS333, TYR334, GLY365 and 16 more
  • 6V0O · PRMT5 bound to the PBM peptide from pICln · SFG A701 · binds PRO314, LEU315, LEU319, TYR324, PHE327, GLU328, LYS333, TYR334 and 17 more
  • 6V0P · PRMT5 complex bound to covalent PBM inhibitor BRD6711 · SFG A704 · binds PRO314, LEU315, TYR324, PHE327, LYS333, TYR334, GLY365, ALA366 and 15 more
  • 6WKQ · 1.98 Angstrom Resolution Crystal Structure of NSP16-NSP10 Heterodimer from SARS-CoV-2 in… · SFG A7103 · binds ASN6841, TYR6845, HIS6867, GLY6869, ALA6870, GLY6871, SER6872, ALA6877 and 13 more
  • 6ZXW · Structure of Archaeoglobus fulgidus Trm11-Trm112 m2G10 tRNA methyltransferase complex… · SFG G401 · binds PRO183, MET184, GLY186, ILE204, ASP205, PHE206, ILE207, ILE210 and 9 more
  • 7CFE · Crystal structure of RsmG methyltransferase of M. tuberculosis · SFG A401 · binds ILE68, GLY69, SER70, GLY71, LEU74, LEU91, GLU92, PRO93 and 10 more
  • 7DSU · Structure of Mod subunit of the Type III restriction-modification enzyme Mbo45V · SFG A601 · binds GLY96, GLU97, ASN98, TYR121, ASP123, PRO124, PRO125, ARG167 and 15 more
  • 7F8C · Crystal structure of rRNA methyltransferase Erm38 in complex with sinefungin · SFG A301 · binds GLN13, ASN14, PHE15, LEU16, GLU38, GLY40, ALA41, GLY42 and 14 more
  • 7NH7 · OC43 coronavirus methyltransferase · SFG A301 · binds ASN43, TYR47, GLY71, ALA72, GLY73, SER74, PRO80, GLY81 and 11 more
  • 7RFK · CamA Adenine Methyltransferase Complexed to Cognate Substrate DNA and Inhibitor Sinefungin · SFG A601 · binds SER27, GLY28, ILE29, TYR30, TYR31, THR32, ASP60, ILE61 and 19 more

Residues it binds most

GLY 88, ASP 73, TYR 78, SER 80, PHE 74, LEU 59, ILE 67, PRO 49, GLU 55, ALA 53 (residue and the binding sites it lines).

Found with

  • EDO · 1,2-ethanediol
  • ZN · Zinc ion
  • CL · Chloride ion
  • GOL · Glycerol
  • SO4 · Sulfate ion
  • PEG · Di(hydroxyethyl)ether
  • TRS · 2-amino-2-hydroxymethyl-propane-1,3-diol
  • XPN · Baeocystin
  • NA · Sodium ion
  • FRU · beta-D-fructofuranose
  • GLC · alpha-D-glucopyranose
  • 9Z1 · (3e,7ar,12as)-6-hydroxy-3-[(1H-imidazol-4-yl) methylidene]-12-methoxy-7A-(2-methylbut-3-en-2-yl)-7A, 12-dihydro-1H,5H-imidazo[1',2':1,2]pyrido[2,3-b]indole-2,5(3H)-dione

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.