UniProt Q9UIQ6
Leucyl-cystinyl aminopeptidase, pregnancy serum form (Q9UIQ6)
Leucyl-cystinyl aminopeptidase, pregnancy serum form (UniProt Q9UIQ6), EC 3.4.11.3: 17 experimental structures on GenesisL1, 12 ligands bound, 72 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q9UIQ6
- Protein
- Leucyl-cystinyl aminopeptidase, pregnancy serum form
- EC
- 3.4.11.3
- Experimental structures
- 17
- Predicted models
- 0
- Ligands
- 12
- Pockets
- 72 · 4 records with a druggable one
Structures
17 records of Q9UIQ6 in the MolNFT archive: 17 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4P8Q | Crystal Structure of Human Insulin Regulated Aminopeptidase with Alanine in Active Site | x-ray diffraction | A, B | — | — |
| 4P8Q | Crystal structure of human insulin regulated aminopeptidase with alanine in active site | x-ray diffraction | A, B | — | — |
| 4PJ6 | Crystal Structure of Human Insulin Regulated Aminopeptidase with Lysine in Active Site | x-ray diffraction | A, B | — | — |
| 4PJ6 | Crystal structure of human insulin regulated aminopeptidase with lysine in active site | x-ray diffraction | A, B | — | — |
| 4Z7I | Crystal structure of insulin regulated aminopeptidase in complex with ligand | x-ray diffraction | A, B | — | — |
| 4Z7I | Crystal structure of insulin regulated aminopeptidase in complex with ligand | x-ray diffraction | A, B | — | — |
| 5C97 | Insulin regulated aminopeptidase | x-ray diffraction | A, B | — | — |
| 5C97 | Insulin regulated aminopeptidase | x-ray diffraction | A, B | — | — |
| 5MJ6 | Ligand-induced conformational change of Insulin-regulated aminopeptidase: insights on catalytic… | x-ray diffraction | A, B | NAG, MAN, BMA, ZN, 7O2, BR | — |
| 5MJ6 | Ligand-induced conformational change of insulin-regulated aminopeptidase: insights on catalytic… | x-ray diffraction | A, B | NAG, MAN, BMA, ZN, 7O2, BR | — |
| 6YDX | Insulin-regulated aminopeptidase complexed with a macrocyclic peptidic inhibitor | x-ray diffraction | A, B | NAG, ONN, ZN, PO4 | 15 (best 0.83) |
| 6YDX | Insulin-regulated aminopeptidase complexed with a macrocyclic peptidic inhibitor | x-ray diffraction | A, B | NAG, ONN, ZN, PO4 | — |
| 7ZYF | Insulin regulated aminopeptidase (IRAP) in complex with a nanomolar alpha hydroxy beta amino acid… | x-ray diffraction | A, B | NAG, MAN, ZN, KFR | 19 (best 0.87) |
| 7ZYF | Insulin regulated aminopeptidase (irap) in complex with a nanomolar alpha hydroxy beta amino acid… | x-ray diffraction | A, B | NAG, MAN, ZN, KFR | — |
| 8CGW | Insulin-regulated aminopeptidase (IRAP) in complex with an allosteric benzopyran-based inhibitor | x-ray diffraction | A, B | NAG, BMA, MAN, ZN, UJX, GLY | 18 (best 0.82) |
| 8P0I | Crystal structure of the open conformation of insulin-regulated aminopeptidase in complex with a… | x-ray diffraction | A, B | NAG, WC3, ZN | 20 (best 0.81) |
| Q9UIQ6 | AlphaFold monomer V2.0 prediction for leucyl-cystinyl aminopeptidase (Q9UIQ6) | — | — | — |
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 8 records
- ZN · Zinc ion · in 8 records
- MAN · alpha-D-mannopyranose · in 5 records
- BMA · beta-D-mannopyranose · in 3 records
- 7O2 · [(2~{S})-2-[[(2~{S})-1-azanyl-1-oxidanylidene-3-phenyl-propan-2-yl]carbamoyl]-4,4-diphenyl-butyl]-[(1~{R})-1-azanyl-3-phenyl-propyl]phosphinic acid · in 2 records
- BR · Bromide ion · in 2 records
- KFR · methyl (2S)-2-[[(2S)-2-[[(2S,3R)-3-azanyl-2-oxidanyl-4-(4-oxidanylphenoxy)butanoyl]amino]-4-methyl-pentanoyl]amino]-3-(1H-indol-3-yl)propanoate · in 2 records
- ONN · 2-[2-[[[(4~{R},8~{S},11~{S})-11-azanyl-8-[(4-hydroxyphenyl)methyl]-6,10-bis(oxidanylidene)-1,2-dithia-5,9-diazacyclotridec-4-yl]carbonylamino]methyl]phenyl]ethanoic acid · in 2 records
- PO4 · Phosphate ion · in 2 records
- GLY · Glycine · in 1 record
- UJX · ethyl 2-acetamido-7-hydroxy-4-(pyridin-3-yl)-4H-chromene-3-carboxylate · in 1 record
- WC3 · 2-[2-(3,5-dimethylpyrazol-1-yl)-6-(4-methoxyphenyl)pyrimidin-4-yl]oxy-N-methyl-N-[(2-methylpyridin-3-yl)methyl]ethanamide · in 1 record
Elsewhere
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