Insulin regulated aminopeptidase (irap) in complex with a nanomolar alpha hydroxy beta amino acid based inhibitor.

Structure

x-ray diffraction · 2 distinct chains.

Ligands and binding sites

• KFR · methyl (2S)-2-[[(2S)-2-[[(2S,3R)-3-azanyl-2-oxidanyl-4-(4-oxidanylphenoxy)butanoyl]amino]-4-methyl-pentanoyl]amino]-3-(1H-indol-3-yl)propanoate · ligand · 2 copies · chains A, B
• NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 29 copies · chains A, B
• BMA · beta-D-mannopyranose · sugar · 5 copies
• MAN · alpha-D-mannopyranose · sugar · 5 copies · chains A, B
• ZN · Zinc ion · metal · 2 copies · chains A, B
• EDO · 1,2-ethanediol · additive · 7 copies · chains A, B
• PEG · Di(hydroxyethyl)ether · additive · 3 copies · chains A
• TRS · 2-amino-2-hydroxymethyl-propane-1,3-diol · additive · chains B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 7ZYF · Insulin regulated aminopeptidase (IRAP) in complex with a nanomolar alpha hydroxy beta… · the same entry in another collection · chain A against A, TM-score 1.00
• Q9UIQ6 · AlphaFold monomer V2.0 prediction for leucyl-cystinyl aminopeptidase (Q9UIQ6) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q9UIQ6
• Elsewhere: RCSB PDB 7ZYF · PDBe 7ZYF · UniProt Q9UIQ6