MolNFT v1 · #115089 · protein

Insulin regulated aminopeptidase

5C97 · Leucyl-cystinyl aminopeptidase: “Insulin regulated aminopeptidase”. X-ray diffraction, 2 ligands (NAG, ZN), 12 pockets (best druggability 0.81). MolNFT v1 #115089 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5C97
Type: protein
Length: 1,711 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Leucyl-cystinyl aminopeptidase
EC: 3.4.11.3
UniProt: Q9UIQ6
Ligands: NAG, ZN
Pockets: 12 · best druggability 0.81

Structure

x-ray diffraction · 2 distinct chains · 43% helix, 20% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Leucyl-cystinyl aminopeptidase (EC 3.4.11.3)	protein	860	44% helix, 20% strand	Q9UIQ6
B	Leucyl-cystinyl aminopeptidase (EC 3.4.11.3)	protein	851	42% helix, 20% strand	Q9UIQ6

Ligands and binding sites

NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 25 copies · chains A, B
ZN · Zinc ion · metal · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

12 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1015	0.81	0.82	105	empty
2	1084	0.80	0.81	112	empty
3	226	0.61	0.81	46	empty
4	165	0.61	0.83	27	empty
5	184	0.60	0.82	30	empty

Interfaces

1 interface between chains.

A–B · 29 Å² buried · 0 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 19 glycan, 1 disulfide (N-glycosylation, disulfide).

Compared structures

5C97 · Insulin regulated aminopeptidase · the same entry in another collection · chain A against A, TM-score 1.00
Q9UIQ6 · AlphaFold monomer V2.0 prediction for leucyl-cystinyl aminopeptidase (Q9UIQ6) · a predicted model of the same protein · chain B against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9UIQ6
Elsewhere: RCSB PDB 5C97 · PDBe 5C97 · UniProt Q9UIQ6

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