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Ligand · ONN

ONN · 2-[2-[[[(4~{R},8~{S},11~{S})-11-azanyl-8-[(4-hydroxyphenyl)methyl]-6,10-bis(oxidanylidene)-1,2-dithia-5,9-diazacyclotridec-4-yl]carbonylamino]methyl]phenyl]ethanoic acid

ONN, 2-[2-[[[(4~{R},8~{S},11~{S})-11-azanyl-8-[(4-hydroxyphenyl)methyl]-6,10-bis(oxidanylidene)-1,2-dithia-5,9-diazacyclotridec-4-yl]carbonylamino]methyl]phenyl]ethanoic acid (C26 H32 N4 O6 S2, 560.7 g/mol), in the MolNFT structures on…

Component
ONN
Formula
C26 H32 N4 O6 S2
Class
ligand
Structures
2
PDB entries
1

Binding sites

ONN in 2 structures; the first of them:

  • 6YDX · Insulin-regulated aminopeptidase complexed with a macrocyclic peptidic inhibitor · ONN A1101 · binds GLU295, ALA427, GLY428, ALA429, MET430, GLU431, LYS460, ILE461 and 12 more
  • 6YDX · Insulin-regulated aminopeptidase complexed with a macrocyclic peptidic inhibitor · ONN A1101 · binds GLU295, GLY428, ALA429, GLU431, LYS460, ILE461, HIS464, GLU465 and 10 more

Residues it binds most

GLU 4, TYR 4, HIS 4, PHE 4, ALA 4, ARG 2, GLY 4, ILE 4, LYS 4, SER 4 (residue and the binding sites it lines).

Found with

  • ZN · Zinc ion
  • BMA · beta-D-mannopyranose
  • NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose
  • PO4 · Phosphate ion
  • EDO · 1,2-ethanediol
  • PEG · Di(hydroxyethyl)ether
  • PG4 · Tetraethylene glycol
  • PGE · Triethylene glycol
  • SIN · Succinic acid

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