UniProt Q9NQ11
Polyamine-transporting ATPase 13A2 (Q9NQ11)
Polyamine-transporting ATPase 13A2 (UniProt Q9NQ11), EC 7.6.2.-: 38 experimental structures and 1 predicted model on GenesisL1, 20 ligands bound, 383 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q9NQ11
- Protein
- Polyamine-transporting ATPase 13A2
- EC
- 7.6.2.-
- Experimental structures
- 38
- Predicted models
- 1
- Ligands
- 20
- Pockets
- 383 · 24 records with a druggable one
Structures
39 records of Q9NQ11 in the MolNFT archive: 38 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7FJM | Cryo EM structure of lysosomal ATPase | electron microscopy | A | — | 16 (best 0.73) |
| 7FJP | Cryo EM structure of lysosomal ATPase | electron microscopy | B | PO4, ADP, MG | 14 (best 0.80) |
| 7FJQ | Cryo EM structure of lysosomal ATPase | electron microscopy | A | SPM | 14 (best 0.72) |
| 7M5V | human ATP13A2 in the AMPPNP-bound occluded state | electron microscopy | A | MG, 1DO, Y01, D10, D12, NAG | 20 (best 0.81) |
| 7M5V | Human ATP13A2 in the amppnp-bound occluded state | electron microscopy | A | MG, 1DO, Y01, D12, D10, NAG | — |
| 7M5X | Human ATP13A2 in the outward-facing E2 state bound to spermine and beryllium fluoride | electron microscopy | A | MG, BEF, Y01, CLR, D10, C14 | 10 (best 0.75) |
| 7M5X | Human ATP13A2 in the outward-facing E2 state bound to spermine and beryllium fluoride | electron microscopy | A | MG, BEF, Y01, CLR, D10, C14 | — |
| 7M5Y | human ATP13A2 in the outward-facing E2 state bound to spermine and magnesium fluoride | electron microscopy | A | MG, MF4, Y01, CLR, D10, C14 | 10 (best 0.75) |
| 7M5Y | Human ATP13A2 in the outward-facing E2 state bound to spermine and magnesium fluoride | electron microscopy | A | MG, MF4, Y01, CLR, D10, C14 | — |
| 7N70 | Cryo-EM structure of ATP13A2 in the BeF-bound E2P-like state | electron microscopy | A | BEF, MG, Y01 | 16 (best 0.79) |
| 7N70 | Cryo-EM structure of ATP13A2 in the bef-bound E2P-like state | electron microscopy | A | BEF, MG, Y01 | — |
| 7N72 | Cryo-EM structure of ATP13A2 in the AlF-bound E2-Pi-like state | electron microscopy | A | ALF, MG, SPM, Y01, PC1 | 13 (best 0.75) |
| 7N72 | Cryo-EM structure of ATP13A2 in the alf-bound E2-pi-like state | electron microscopy | A | ALF, MG, SPM, Y01, PC1 | — |
| 7N73 | Cryo-EM structure of ATP13A2 in the ADP-AlF-bound E1P-ADP-like state | electron microscopy | A | ADP, ALF, MG, Y01 | 15 (best 0.80) |
| 7N73 | Cryo-EM structure of ATP13A2 in the ADP-alf-bound E1P-ADP-like state | electron microscopy | A | ADP, ALF, MG, Y01 | — |
| 7N74 | Cryo-EM structure of ATP13A2 D508N mutant in the E1-ATP-like state | electron microscopy | A | ATP, MG, Y01 | 16 (best 0.81) |
| 7N74 | Cryo-EM structure of ATP13A2 D508N mutant in the E1-ATP-like state | electron microscopy | A | ATP, MG, Y01 | — |
| 7N76 | Cryo-EM structure of ATP13A2 D458N/D962N mutant in the E1-apo state, Conformation 2 | electron microscopy | A | — | 15 (best 0.73) |
| 7N76 | Cryo-EM structure of ATP13A2 D458N/D962N mutant in the E1-apo state, conformation 2 | electron microscopy | A | — | — |
| 7N77 | Cryo-EM structure of ATP13A2 D458N/D962N mutant in the AlF-bound E1P-like state | electron microscopy | A | ALF, MG, Y01 | 19 (best 0.68) |
| 7N77 | Cryo-EM structure of ATP13A2 D458N/D962N mutant in the alf-bound E1P- like state | electron microscopy | A | ALF, MG, Y01 | — |
| 7N78 | Cryo-EM structure of ATP13A2 in the E2-Pi state | electron microscopy | A | PO4, MG, SPM, Y01, PC1 | 14 (best 0.74) |
| 7N78 | Cryo-EM structure of ATP13A2 in the E2-pi state | electron microscopy | A | PO4, MG, SPM, Y01, PC1 | — |
| 7VPI | Cryo-EM structure of the human ATP13A2 (E1-ATP state) | electron microscopy | A | ACP, MG | 11 (best 0.83) |
| 7VPI | Cryo-EM structure of the human ATP13A2 (E1-ATP state) | electron microscopy | A | ACP, MG | — |
| 7VPJ | Cryo-EM structure of the human ATP13A2 (E1P-ADP state) | electron microscopy | A | MG, ADP, NAG, ALF | 15 (best 0.81) |
| 7VPJ | Cryo-EM structure of the human ATP13A2 (E1P-ADP state) | electron microscopy | A | MG, ADP, NAG, ALF | — |
| 7VPK | Cryo-EM structure of the human ATP13A2 (SPM-bound E2P state) | electron microscopy | A | NAG, MG, BEF, SPM | 16 (best 0.75) |
| 7VPK | Cryo-EM structure of the human ATP13A2 (spm-bound E2P state) | electron microscopy | A | NAG, MG, BEF, SPM | — |
| 7VPL | Cryo-EM structure of the human ATP13A2 (SPM-bound E2Pi state) | electron microscopy | A | NAG, MG, ALF, SPM | 16 (best 0.76) |
| 7VPL | Cryo-EM structure of the human ATP13A2 (spm-bound E2PI state) | electron microscopy | A | NAG, MG, ALF, SPM | — |
| 8IEK | Cryo-EM structure of ATP13A2 in the E1-ATP state | electron microscopy | P | ATP, MG | 15 (best 0.83) |
| 8IEL | Cryo-EM structure of ATP13A2 in the E1-like state | electron microscopy | P | — | 20 (best 0.84) |
| 8IEM | Cryo-EM structure of ATP13A2 in the E2P state | electron microscopy | P | SPM, MG, BEF | 20 (best 0.83) |
| 8IEN | Cryo-EM structure of ATP13A2 in the E2-Pi state | electron microscopy | P | MG, ALF, SPM | 18 (best 0.75) |
| 8IEO | Cryo-EM structure of ATP13A2 in the nominal E1P state | electron microscopy | P | ALF, MG, SPM | 20 (best 0.79) |
| 8IER | Cryo-EM structure of ATP13A2 in the putative of E2 state | electron microscopy | P | SPM | 20 (best 0.86) |
| 8IES | Cryo-EM structure of ATP13A2 in the E1P-ADP state | electron microscopy | P | ALF, MG, ADP | 20 (best 0.85) |
| Q9NQ11 | AlphaFold monomer V2.0 prediction for polyamine-transporting ATPase 13A2 (Q9NQ11) | predicted | A | — | — |
Ligands
- MG · Magnesium ion · in 32 records
- Y01 · Cholesterol hemisuccinate · in 18 records
- ALF · Tetrafluoroaluminate ion · in 13 records
- SPM · Spermine · in 13 records
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 12 records
- BEF · Beryllium trifluoride ion · in 7 records
- ADP · Adenosine-5'-diphosphate · in 6 records
- D10 · Decane · in 6 records
- D12 · Dodecane · in 6 records
- EUJ · (2R)-3-{[(S)-hydroxy{[(1s,2r,3r,4s,5s,6r)-2,4,6-trihydroxy-3,5-bis(phosphonooxy) cyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctanoate · in 6 records
- C14 · Tetradecane · in 4 records
- CLR · Cholesterol · in 4 records
- PC1 · 1,2-diacyl-sn-glycero-3-phosphocholine · in 4 records
- SPK · Spermine (fully protonated form) · in 4 records
- ATP · Adenosine-5'-triphosphate · in 3 records
- PO4 · Phosphate ion · in 3 records
- 1DO · 1-dodecanol · in 2 records
- ACP · Phosphomethylphosphonic acid adenylate ester · in 2 records
- ANP · Phosphoaminophosphonic acid-adenylate ester · in 2 records
- MF4 · Tetrafluoromagnesate(2-) · in 2 records
Experiment against prediction
- 7VPI chain A against the predicted model Q9NQ11: TM-score 0.95, RMSD 2.39 Å
- 7VPI chain A against the predicted model Q9NQ11: TM-score 0.95, RMSD 2.39 Å
- 7VPJ chain A against the predicted model Q9NQ11: TM-score 0.95, RMSD 2.39 Å
- 7VPJ chain A against the predicted model Q9NQ11: TM-score 0.95, RMSD 2.39 Å
- 7FJP chain B against the predicted model Q9NQ11: TM-score 0.95, RMSD 2.42 Å
- 7N73 chain A against the predicted model Q9NQ11: TM-score 0.95, RMSD 2.53 Å
- 7N73 chain A against the predicted model Q9NQ11: TM-score 0.95, RMSD 2.53 Å
- 7M5V chain A against the predicted model Q9NQ11: TM-score 0.95, RMSD 2.59 Å
- 7M5V chain A against the predicted model Q9NQ11: TM-score 0.95, RMSD 2.59 Å
- 7N74 chain A against the predicted model Q9NQ11: TM-score 0.94, RMSD 2.68 Å
Elsewhere
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