UniProt Q9NP58
ATP-binding cassette sub-family B member 6 (Q9NP58)
ATP-binding cassette sub-family B member 6 (UniProt Q9NP58), EC 7.6.2.5: 21 experimental structures and 1 predicted model on GenesisL1, 8 ligands bound, 106 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q9NP58
- Protein
- ATP-binding cassette sub-family B member 6
- EC
- 7.6.2.5
- Experimental structures
- 21
- Predicted models
- 1
- Ligands
- 8
- Pockets
- 106 · 6 records with a druggable one
Structures
22 records of Q9NP58 in the MolNFT archive: 21 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3NH6 | Nucleotide Binding Domain of human ABCB6 (apo structure) | x-ray diffraction | A | — | — |
| 3NH6 | Nucleotide binding domain of human ABCB6 (apo structure) | x-ray diffraction | A | — | — |
| 3NH9 | Nucleotide Binding Domain of Human ABCB6 (ATP bound structure) | x-ray diffraction | A | — | — |
| 3NH9 | Nucleotide binding domain of human ABCB6 (ATP bound structure) | x-ray diffraction | A | — | — |
| 3NHA | Nucleotide Binding Domain of Human ABCB6 (ADP Mg bound structure) | x-ray diffraction | A | — | — |
| 3NHA | Nucleotide binding domain of human ABCB6 (ADP mg bound structure) | x-ray diffraction | A | — | — |
| 3NHB | Nucleotide Binding Domain of Human ABCB6 (ADP bound structure) | x-ray diffraction | A | — | — |
| 3NHB | Nucleotide binding domain of human ABCB6 (ADP bound structure) | x-ray diffraction | A | — | — |
| 7D7N | Cryo-EM structure of human ABCB6 transporter | electron microscopy | A, B | — | 14 (best 0.79) |
| 7D7N | Cryo-EM structure of human ABCB6 transporter | electron microscopy | A, B | — | — |
| 7D7R | Cryo-EM structure of the core domain of human ABCB6 transporter | electron microscopy | A, B | — | 18 (best 0.85) |
| 7D7R | Cryo-EM structure of the core domain of human ABCB6 transporter | electron microscopy | A, B | — | — |
| 7DNY | Cryo-EM structure of the human ABCB6 (coproporphyrin III-bound) | electron microscopy | A, B | Y01, HT9 | — |
| 7DNZ | Cryo-EM structure of the human ABCB6 (hemin and gsh-bound) | electron microscopy | A, B | GSH, Y01, HEM | — |
| 7EKL | Mitochondrial outer membrane protein | electron microscopy | A, B | ATP, MG | 19 (best 0.86) |
| 7EKL | Mitochondrial outer membrane protein | electron microscopy | A, B | ATP, MG | — |
| 7EKM | Mitochondrial outer membrane protein | electron microscopy | A, B | — | — |
| 7EKM | Mitochondrial outer membrane protein | electron microscopy | A, B | — | — |
| 8FWK | CryoEM structure of Human ABCB6 Transporter | electron microscopy | B, A | — | 16 (best 0.87) |
| 8K7B | post-occluded structure of human ABCB6 W546A mutant (ADP/VO4-bound) | electron microscopy | A, B | PEV, AOV, MG | 19 (best 0.87) |
| 9DBQ | Cryo-EM structure of human ABCB6 transporter in an inward-facing conformation | electron microscopy | A, B | Y01 | 20 (best 0.86) |
| Q9NP58 | AlphaFold monomer V2.0 prediction for ATP-binding cassette sub-family B member 6, mitochondrial… | predicted | A | — | — |
Ligands
- MG · Magnesium ion · in 3 records
- Y01 · Cholesterol hemisuccinate · in 3 records
- ATP · Adenosine-5'-triphosphate · in 2 records
- AOV · Adp orthovanadate · in 1 record
- GSH · Glutathione · in 1 record
- HEM · Protoporphyrin IX containing Fe · in 1 record
- HT9 · coproporphyrin III · in 1 record
- PEV · (1S)-2-{[(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-1-[(palmitoyloxy)methyl]ethyl stearate · in 1 record
Experiment against prediction
- 7DNZ chain B against the predicted model Q9NP58: TM-score 0.97, RMSD 1.77 Å
- 7DNZ chain A against the predicted model Q9NP58: TM-score 0.96, RMSD 1.78 Å
- 7D7R chain B against the predicted model Q9NP58: TM-score 0.92, RMSD 2.81 Å
- 7D7R chain B against the predicted model Q9NP58: TM-score 0.92, RMSD 2.81 Å
- 7D7R chain A against the predicted model Q9NP58: TM-score 0.92, RMSD 2.81 Å
- 7D7R chain A against the predicted model Q9NP58: TM-score 0.92, RMSD 2.81 Å
- 3NHA chain A against the predicted model Q9NP58: TM-score 0.90, RMSD 2.22 Å
- 3NHA chain A against the predicted model Q9NP58: TM-score 0.90, RMSD 2.22 Å
- 3NHB chain A against the predicted model Q9NP58: TM-score 0.90, RMSD 2.13 Å
- 3NHB chain A against the predicted model Q9NP58: TM-score 0.90, RMSD 2.13 Å
Elsewhere
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