MolNFT v1 · #175972 · protein

Cryo-EM structure of human ABCB6 transporter

7D7N · ATP-binding cassette sub-family B member 6, mitochondrial: “Cryo-EM structure of human ABCB6 transporter”. Electron microscopy, 14 pockets (best druggability 0.79). MolNFT v1 #175972 on GenesisL1: 3D structure, binding sites and…

PDB: 7D7N
Type: protein
Length: 1,408 residues
Chains: 2
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: ATP-binding cassette sub-family B member 6, mitochondrial
UniProt: Q9NP58
Pockets: 14 · best druggability 0.79

Structure

electron microscopy · 1 distinct chain · 66% helix, 7% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	ATP-binding cassette sub-family B member 6, mitochondrial	protein	704	66% helix, 7% strand	Q9NP58

Pockets

14 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1002	0.79	0.81	131	empty
2	864	0.78	0.81	107	empty
3	891	0.78	0.81	95	empty
4	809	0.77	0.81	89	empty
5	859	0.70	0.76	66	empty

Interfaces

1 interface between chains.

A–B · 961 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

7D7N · Cryo-EM structure of human ABCB6 transporter · the same entry in another collection · chain A against A, TM-score 1.00
Q9NP58 · AlphaFold monomer V2.0 prediction for ATP-binding cassette sub-family B member 6… · a predicted model of the same protein · chain B against A, TM-score 0.76

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9NP58
Elsewhere: RCSB PDB 7D7N · PDBe 7D7N · UniProt Q9NP58

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